{
  "abstract": "Availability of commercial antibodies for immunochemistry is typically limited to major model species. Researchers working on non-model organisms therefore often need either to generate novel species-specific antibodies or venture into expensive empirical screening from available antibody catalogues, hoping to find cross-reactive reagents. SixPack-AbScan is a free web server aiding researchers in transferring antibodies across species: using the available epitope-mapping information, the software performs a simple computational pre-screening of potential cross-reactivity. The workflow is species-agnostic and designed to help non-model-species researchers prioritize antibodies for experimental validation. A hit indicates sequence-level conservation of the epitopes and a high probability of cross-reactivity; the server does not model substitutions, structure, accessibility, expression or binding affinity. The web server is available at https://sixpack-abscan.serve.scilifelab.se.",
  "abstract_shown": true,
  "affiliations": [
    "Science for Life Laboratory, Stockholms Universitet"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "M. Grillo"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6a2fas6snjk9k.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.10.746162",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.746162v1.full",
  "id": "6a2fas6snjk9k",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.746162v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioinformatics"
    ],
    [
      "openalex",
      "2741|Monoclonal and Polyclonal Antibodies Research"
    ]
  ],
  "openalex": "W7213279654",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.746162v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6a2fas6snjk9k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:37Z",
      "native_id": "10.64898/2026.09.10.746162",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.10.746162v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioinformatics",
      "subfield": "bioinformatics"
    }
  ],
  "title": "SixPack-AbScan: a web server to discover cross-reactivity of antibodies across species",
  "title_text": "SixPack-AbScan: a web server to discover cross-reactivity of antibodies across species",
  "type": "preprint",
  "updated_at": "2026-10-30T12:22:37Z",
  "url": "https://research.draconitic.com/paper/6a2fas6snjk9k",
  "venue": "bioRxiv",
  "versions": []
}