{
  "abstract": "Objective\n\nTo evaluate the predictive value of monocyte-to-high-density lipoprotein cholesterol ratio (MHR), plasma atherogenic index (AIP), and baseline National Institutes of Health Stroke Scale (NIHSS) score for 1-year major adverse cardiovascular and cerebrovascular events (MACCE) after acute ischemic stroke, and to explore potential differences in their predictive patterns across endpoint subtypes.Methods\n\nThis retrospective study enrolled 429 elderly patients (≥65 years) with acute ischemic stroke admitted to Lu'an People's Hospital (Anhui, China) between January 2020 and September 2023. Clinical and laboratory data were collected; MHR and AIP were Z-standardized. Patients were followed for 1 year for MACCE (stroke recurrence, all-cause mortality, non-fatal myocardial infarction/angina). Independent predictors were identified using multivariable logistic regression (Enter method: full model, then parsimonious model). Receiver operating characteristic (ROC) curves and DeLong tests compared individual and combined (MHR+AIP+baseline NIHSS) models. Endpoint-specific analyses were exploratory. Bootstrap resampling was performed for internal validation.Results\n\nMACCE occurred in 115 patients (26.8%), comprising 58 stroke recurrences, 41 deaths, and 17 coronary events. MHR (per 1-SD increase: OR=2.765, 95% CI: 2.062-3.707, P<0.001), AIP (per 1-SD increase: OR=1.682, 95% CI: 1.289-2.193, P<0.001), and Baseline NIHSS score (OR=1.170, 95% CI: 1.108-1.235, P<0.001) were independent predictors of MACCE. In exploratory endpoint-specific analyses, MHR was associated with all three subtypes, while AIP was associated with stroke recurrence and coronary events but not all-cause mortality. However, formal interaction tests were underpowered. AUCs were 0.731 (MHR), 0.628 (AIP), 0.646 (NIHSS), and 0.810 (combined); the combined model outperformed all individual markers (all P<0.05 by DeLong test).Conclusion\n\nMHR and AIP independently predict 1-year MACCE in elderly stroke patients. The observed differences in their associations across endpoint subtypes are exploratory and hypothesis-generating; formal interaction tests or adequately powered prospective studies are required. The combined model may improve risk stratification, but requires prospective validation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Lu'an People's Hospital, Lu'an, Anhui, People's Republic of China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhengling Liang"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenxia Hu"
    },
    {
      "affs": [
        0
      ],
      "name": "Chitian Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Hui Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Feng Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6a4y898evhtq9.bib",
  "cited_by": 0,
  "doi": "10.2147/cia.s622634",
  "fulltext_url": "https://europepmc.org/articles/PMC13726508",
  "id": "6a4y898evhtq9",
  "issns": [
    "1176-9092",
    "1178-1998"
  ],
  "landing_url": "https://europepmc.org/article/MED/42974147",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2713|Acute Ischemic Stroke Management"
    ]
  ],
  "openalex": "W7224181311",
  "pdf_url": "https://europepmc.org/articles/PMC13726508?pdf=render",
  "pmcid": "PMC13726508",
  "pmid": "42974147",
  "published": "2026-10-29",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/6a4y898evhtq9.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "MED:42974147",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42974147"
    },
    {
      "first_seen": "2026-11-05T12:22:50Z",
      "native_id": "PMC13726508",
      "source": "pmc",
      "url": "https://doi.org/10.2147/cia.s622634"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Acute Ischemic Stroke Management",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "MHR and AIP as Differential Predictors of 1-Year Major Adverse Cardiovascular and Cerebrovascular Events After Acute Ischemic Stroke: A Combined Model Study.",
  "title_text": "MHR and AIP as Differential Predictors of 1-Year Major Adverse Cardiovascular and Cerebrovascular Events After Acute Ischemic Stroke: A Combined Model Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:22:50Z",
  "url": "https://research.draconitic.com/paper/6a4y898evhtq9",
  "venue": "Clinical interventions in aging",
  "versions": []
}