{
  "abstract": "Pharmacological activation of Piezo1 by Yoda1 suppresses mechanosensitive urothelial ATP release through Ca 2+ -dependent connexin hemichannel closure and Ca 2+ -independent mechanisms. In BOO rats, intravesical Yoda1 reduces elevated ATP levels and attenuates bladder overactivity without impairing voiding function, identifying Piezo1 as a novel therapeutic target for BOO-induced lower urinary tract dysfunction.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA",
    "Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan",
    "Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA",
    "Department of Mechanical Engineering and Materials Science, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
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        1
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      "name": "Shingo Kimura"
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    {
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      "name": "Kanako Matsuoka"
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      "name": "Ádám Lénárt"
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      "name": "Stephanie L Daugherty"
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    {
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      "name": "Akihiro Ito"
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      "name": "Anne Robertson"
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    {
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        0,
        2
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      "name": "Naoki Yoshimura"
    },
    {
      "affs": [
        2
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      "name": "Jonathan M. Beckel"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6a7ppvangqz25.bib",
  "cited_by": 0,
  "doi": "10.1152/ajpcell.00426.2026",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722994/",
  "id": "6a7ppvangqz25",
  "issns": [
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  "landing_url": "https://doi.org/10.1152/ajpcell.00426.2026",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
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  "native_subjects": [
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      "2748|Urinary Bladder and Prostate Research"
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  "pdf_url": null,
  "pmcid": "PMC13722994",
  "pmid": "42837627",
  "published": "2026-10-06",
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  "ris": "https://research.draconitic.com/paper/6a7ppvangqz25.ris",
  "sources": [
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      "first_seen": "2026-11-04T12:21:41Z",
      "native_id": "PMC13722994",
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      "url": "https://doi.org/10.1152/ajpcell.00426.2026"
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  "subjects": [
    {
      "field": "biochemistry",
      "origin": "journal-openalex:1312|Ion Transport and Channel Regulation",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Piezo1 Activation by Yoda1 Inhibits Mechanosensitive ATP Release in Human Urothelial Cells and Bladder Overactivity in Rats with Bladder Outlet Obstruction",
  "title_text": "Piezo1 Activation by Yoda1 Inhibits Mechanosensitive ATP Release in Human Urothelial Cells and Bladder Overactivity in Rats with Bladder Outlet Obstruction",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:41Z",
  "url": "https://research.draconitic.com/paper/6a7ppvangqz25",
  "venue": "American journal of physiology. Cell physiology",
  "versions": []
}