{
  "abstract": "Fibro-adipogenic progenitors (FAPs) are muscle-resident mesenchymal stromal cells essential for homeostasis and regeneration but can produce fibrosis or intramuscular fat in pathological conditions. Insulin-like growth factor-I (IGF-I) regulates regeneration through actions on muscle fibers, satellite cells, macrophages, and extracellular matrix (ECM) remodeling but has multiple sources. To assess the role of FAP-derived IGF-I, we generated inducible FAP-specific Igf1 -deficient (FID) mice. Following BaCl 2 injury, FID muscles displayed impaired regeneration, with smaller fibers, fewer Pax7 + and MyoD + cells, increased CD68 + macrophages, decreased collagen, and suppressed FAP proliferation. After glycerol-induced injury, FID muscles had reduced fat. Primary FID FAPs displayed blunted proliferation, upregulated immune-regulatory genes, and downregulated ECM and growth genes, with delayed fibrogenic and adipogenic differentiation. scRNA-seq of homeostatic muscle revealed reduced protein translation and ECM indices alongside increased senescence markers in FID samples. Taken together, FAP IGF-I is critical for FAP function, with direct and indirect impact on muscle regeneration.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA; Myology Institute, University of Florida, Gainesville, FL, USA",
    "Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA",
    "Interdisciplinary Center for Biotechnology Research, University of Florida, Gainesville, FL, USA",
    "Department of Animal Sciences, University of Florida, Gainesville, FL, USA",
    "Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA",
    "Myology Institute, University of Florida, Gainesville, FL, USA; Department of Animal Sciences, University of Florida, Gainesville, FL, USA",
    "Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA; Myology Institute, University of Florida, Gainesville, FL, USA",
    "Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA; Myology Institute, University of Florida, Gainesville, FL, USA. Electronic address: erbarton@ufl.edu"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yangyi E. Luo",
      "orcid": "0000-0001-7418-0030"
    },
    {
      "affs": [
        1
      ],
      "name": "Zoe Abe-Teh"
    },
    {
      "affs": [
        1
      ],
      "name": "Tarek Y. Alsaghir"
    },
    {
      "affs": [
        1
      ],
      "name": "Li-Ying Kuo",
      "orcid": "0009-0001-7765-5385"
    },
    {
      "affs": [
        2
      ],
      "name": "Fahong Yu",
      "orcid": "0000-0002-9342-6419"
    },
    {
      "affs": [
        1
      ],
      "name": "Bradley E. Stoker"
    },
    {
      "affs": [
        3
      ],
      "name": "Yumei Zhou"
    },
    {
      "affs": [
        4
      ],
      "name": "Ambili Bai Appu",
      "orcid": "0009-0005-3543-9229"
    },
    {
      "affs": [
        1
      ],
      "name": "Elijah M. Dy"
    },
    {
      "affs": [
        5
      ],
      "name": "Feng Yue",
      "orcid": "0000-0002-5856-3506"
    },
    {
      "affs": [
        6
      ],
      "name": "Daniel Kopinke",
      "orcid": "0000-0001-5148-8219"
    },
    {
      "affs": [
        7
      ],
      "name": "Elisabeth R. Barton",
      "orcid": "0000-0002-7401-4398"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6b8csxjhg9e4f.bib",
  "cited_by": 11,
  "doi": "10.1016/j.stemcr.2026.102973",
  "fulltext_url": null,
  "id": "6b8csxjhg9e4f",
  "issns": [
    "2213-6711"
  ],
  "landing_url": "https://doi.org/10.1016/j.stemcr.2026.102973",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Muscle Physiology and Disorders"
    ]
  ],
  "openalex": "W7165857488",
  "pdf_url": null,
  "pmcid": "PMC12027368",
  "pmid": "40291730",
  "published": "2026-06-25",
  "publisher": "Elsevier BV",
  "ris": "https://research.draconitic.com/paper/6b8csxjhg9e4f.ris",
  "sources": [
    {
      "first_seen": "2026-11-05T13:20:47Z",
      "native_id": "W7165857488",
      "source": "openalex",
      "url": "https://doi.org/10.1016/j.stemcr.2026.102973"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Muscle Physiology and Disorders",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Resident mesenchymal progenitor cells require autocrine IGF-I in homeostatic and regenerating skeletal muscle",
  "title_text": "Resident mesenchymal progenitor cells require autocrine IGF-I in homeostatic and regenerating skeletal muscle",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T13:20:43Z",
  "url": "https://research.draconitic.com/paper/6b8csxjhg9e4f",
  "venue": "Stem Cell Reports",
  "versions": []
}