{
  "abstract": "Single-molecule localization microscopy commonly reconstructs images from estimated emitter coordinates. We calculate maximum-likelihood localization maps (MLLM), a non-iterative approach that evaluates positional likelihood from measured data and a supplied point-spread function. The MLLM of each detected single molecule image is added into a final upsampled image representing the overall molecular probability map, preserving the positional likelihood structure and obviating separate coordinate-based rendering. MLLM calculation is noniterative, fast, supports any calibrated point-spread function, accounts for local background variation, supports two- and three-dimensional reconstruction, and can be calculated in parallel.",
  "abstract_shown": true,
  "affiliations": [
    "Leibniz Institute of Photonic Technology, Institute of Physical Chemistry, Frierich Schiller University Jena, Abbe Center of Photonics"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "H. Zarei Oshtolagh"
    },
    {
      "name": "R. Foerster"
    },
    {
      "name": "J. Ries"
    },
    {
      "affs": [
        0
      ],
      "name": "R. Heintzmann"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6b8edbr3kwpkc.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.11.05.764521",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.11.05.764521v1.full",
  "id": "6b8edbr3kwpkc",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.11.05.764521v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "biophysics"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.11.05.764521v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6b8edbr3kwpkc.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T00:21:14Z",
      "native_id": "10.64898/2026.11.05.764521",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.11.05.764521v1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "biorxiv:biophysics",
      "subfield": "biophysics"
    }
  ],
  "title": "Maximum Likelihood Localization Maps",
  "title_text": "Maximum Likelihood Localization Maps",
  "type": "preprint",
  "updated_at": "2026-11-08T00:21:05Z",
  "url": "https://research.draconitic.com/paper/6b8edbr3kwpkc",
  "venue": "bioRxiv",
  "versions": []
}