{
  "abstract": "Peripheral nerve injuries impose a substantial strain on the lives of millions of people worldwide. Engineered neural tissues provide a promising avenue to improve peripheral nerve repair strategies, potentially allowing the precise seeding of cells and materials that support regenerative processes. Current optimization of cell-seeding strategies relies on testing the impact of relevant parameters in vivo, requiring considerable time and resources. We propose an alternative approach to the design of cellular hydrogels based on a mathematical cell–solute model, informed via in vitro experiment, to identify promising cell-seeding strategies in silico at a limited cost. These designs are manufactured using 3D-printed moulds and validated in vivo. We evaluate the regenerative potential of these designs by focusing on the impact of different cell-seeding strategies on vascular endothelial growth factor secretion and gradient generation, both crucial elements of regenerative angiogenesis in early nerve repair. In this way, we provide a first proof-of-concept of a digital twin for nerve tissue engineering, which uses in silico, in vitro and in vivo repair models.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Owein Guillemot-Legris"
    },
    {
      "name": "Maxime Berg"
    },
    {
      "name": "Poppy O. Smith"
    },
    {
      "name": "James B. Phillips"
    },
    {
      "name": "Rebecca J. Shipley"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6bp1ed7drm2jb.bib",
  "cited_by": 0,
  "doi": "10.1098/rsif.2025.0879",
  "fulltext_url": null,
  "id": "6bp1ed7drm2jb",
  "issns": [
    "1742-5689",
    "1742-5662"
  ],
  "landing_url": "https://hal.science/hal-05849078v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "0.spi"
    ],
    [
      "openalex",
      "2804|Nerve injury and regeneration"
    ]
  ],
  "openalex": "W7165646159",
  "pdf_url": "https://hal.science/hal-05849078/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-06-24",
  "publisher": "the Royal Society",
  "ris": "https://research.draconitic.com/paper/6bp1ed7drm2jb.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:20:18Z",
      "native_id": "hal-05849078",
      "source": "hal",
      "url": "https://hal.science/hal-05849078v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2804|Nerve injury and regeneration",
      "subfield": "neuroscience"
    }
  ],
  "title": "Bridging the gap: towards a digital twin to optimize therapeutic cell-seeding strategies in nerve tissue engineering",
  "title_text": "Bridging the gap: towards a digital twin to optimize therapeutic cell-seeding strategies in nerve tissue engineering",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:20:49Z",
  "url": "https://research.draconitic.com/paper/6bp1ed7drm2jb",
  "venue": "Journal of the Royal Society Interface",
  "versions": []
}