{
  "abstract": "Alzheimer’s disease and primary tauopathies are marked by changes in adaptive immunity, with increased brain CD8+ T cells correlating with tau pathology severity. However, how peripheral T cells get primed to enter the brain and contribute to tau-mediated neurodegeneration remains unclear. In different disease conditions, conventional type 1 dendritic cells (cDC1s) cross-present antigens to prime CD8+ T cells into effector cells. We show that tauopathy mice lacking cDC1s or antigen cross-presentation are protected from neurodegeneration, with reduced brain CD8+ T cell infiltration and glial activation. The remaining CD8+ T cells exhibit limited clonal expansion, consistent with impaired priming. We further demonstrate that brain-derived antigens are presented in secondary lymphoid tissues, suggesting a site of T cell activation. Together, these findings establish cDC1-dependent peripheral priming as a key driver of CD8+ T cell accumulation in the brain and tau-mediated neurodegeneration.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA",
    "Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA",
    "Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA",
    "Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA",
    "Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St Louis, MO, USA",
    "Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA",
    "Bursky Center for Human Immunology, Washington University School of Medicine, St. Louis, MO, USA",
    "McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA",
    "Needleman Center for Neurometabolism and Axonal Therapeutics, St. Louis, MO, USA",
    "Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA",
    "Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA. ulrichj@wustl.edu",
    "Center for Brain Immunology and Glia (BIG), Washington University School of Medicine, St Louis, MO, USA. holtzman@wustl.edu",
    "Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA. holtzman@wustl.edu"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 31,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Hao Hu",
      "orcid": "0000-0003-3622-9897"
    },
    {
      "affs": [
        0
      ],
      "name": "Peter Bor‐Chian Lin",
      "orcid": "0000-0002-8954-9045"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Carisa Zeng",
      "orcid": "0000-0002-7108-3873"
    },
    {
      "affs": [
        0
      ],
      "name": "Yongyi Li",
      "orcid": "0009-0009-1001-3095"
    },
    {
      "affs": [
        0
      ],
      "name": "Megan E. Bosch",
      "orcid": "0000-0003-1404-6870"
    },
    {
      "affs": [
        0
      ],
      "name": "Joshua T. Emmerson",
      "orcid": "0000-0001-6007-4341"
    },
    {
      "affs": [
        0
      ],
      "name": "Prabal Sharma"
    },
    {
      "affs": [
        2
      ],
      "name": "Ray A. Ohara",
      "orcid": "0000-0001-7897-3169"
    },
    {
      "affs": [
        3
      ],
      "name": "Wendy Dong",
      "orcid": "0000-0002-5663-7372"
    },
    {
      "affs": [
        3
      ],
      "name": "Tong Wu",
      "orcid": "0000-0001-9121-2495"
    },
    {
      "affs": [
        4,
        2
      ],
      "name": "Siling Du",
      "orcid": "0000-0003-1540-3585"
    },
    {
      "affs": [
        4,
        2
      ],
      "name": "Wenqing Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Hong Jiang",
      "orcid": "0000-0002-0038-8960"
    },
    {
      "affs": [
        3
      ],
      "name": "Liya Yuan",
      "orcid": "0000-0003-3630-0294"
    },
    {
      "affs": [
        0
      ],
      "name": "Xin Bao",
      "orcid": "0000-0002-2064-5266"
    },
    {
      "affs": [
        5
      ],
      "name": "Shasha Li"
    },
    {
      "affs": [
        6
      ],
      "name": "Anthony N. Vomund",
      "orcid": "0000-0001-8513-7118"
    },
    {
      "affs": [
        6
      ],
      "name": "Petra Erdmann-Gilmore",
      "orcid": "0000-0002-3949-9801"
    },
    {
      "affs": [
        0
      ],
      "name": "Yichen Gu"
    },
    {
      "affs": [
        0
      ],
      "name": "Miwei Hu",
      "orcid": "0000-0002-5793-5101"
    },
    {
      "affs": [
        0
      ],
      "name": "Jonathan Nulman",
      "orcid": "0000-0002-8887-4532"
    },
    {
      "affs": [
        0
      ],
      "name": "Timothy M. Miller",
      "orcid": "0000-0002-3424-5511"
    },
    {
      "affs": [
        6,
        5
      ],
      "name": "Wayne M. Yokoyama",
      "orcid": "0000-0002-0566-7264"
    },
    {
      "affs": [
        6,
        4,
        2
      ],
      "name": "Cheryl F. Lichti",
      "orcid": "0000-0003-4099-4954"
    },
    {
      "affs": [
        3,
        7,
        8
      ],
      "name": "Jeffrey Milbrandt",
      "orcid": "0000-0002-5477-7689"
    },
    {
      "affs": [
        0,
        9
      ],
      "name": "Richard J. Perrin",
      "orcid": "0000-0002-3443-7716"
    },
    {
      "affs": [
        4,
        2
      ],
      "name": "Jonathan Kipnis",
      "orcid": "0000-0002-3714-517X"
    },
    {
      "affs": [
        2
      ],
      "name": "Maxim N. Artyomov",
      "orcid": "0000-0002-1133-4212"
    },
    {
      "affs": [
        2
      ],
      "name": "KENNETH M. M. MURPHY",
      "orcid": "0000-0002-3505-9630"
    },
    {
      "affs": [
        10
      ],
      "name": "Jason D. Ulrich",
      "orcid": "0000-0002-4743-926X"
    },
    {
      "affs": [
        11,
        12
      ],
      "name": "David M. Holtzman",
      "orcid": "0000-0002-3400-0856"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6c1s5sxxp7j3b.bib",
  "cited_by": 5,
  "doi": "10.1038/s41593-026-02427-5",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13724275/",
  "id": "6c1s5sxxp7j3b",
  "issns": [
    "1097-6256",
    "1546-1726"
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  "landing_url": "https://doi.org/10.1038/s41593-026-02427-5",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
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  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
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      "2737|Alzheimer's disease research and treatments"
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      "2804|Alzheimer's disease research and treatments"
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  "pmcid": "PMC13724275",
  "pmid": "42693199",
  "published": "2026-09-03",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/6c1s5sxxp7j3b.ris",
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  "subjects": [
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      "field": "biology",
      "origin": "openalex:2804|Alzheimer's disease research and treatments",
      "subfield": "neuroscience"
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    {
      "field": "medicine",
      "origin": "openalex:2737|Alzheimer's disease research and treatments",
      "subfield": "physiology"
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  ],
  "title": "Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration",
  "title_text": "Priming of CD8+ T cells by peripheral dendritic cells exacerbates tau-mediated neurodegeneration",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T13:21:14Z",
  "url": "https://research.draconitic.com/paper/6c1s5sxxp7j3b",
  "venue": "Nature Neuroscience",
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