{
  "abstract": "INTRODUCTION: F-choline (FCH) PET has emerged as a highly performant imaging technique for guiding parathyroidectomy. As cure is the goal of surgery, the main aims of this study were to summarize patient-based sensitivity, positive predictive value (PPV), and cure rate of FCH PET guided surgery in the surgical management of pHPT. EVIDENCE ACQUISITION: We conducted a systematic review and metaanalysis according to the PRISMA Guidelines. A literature search was performed in the PubMed, Web of Science and Cochrane databases, last updated November 2022. Original articles on choline PET in patients with pHPT mentioning patient-based sensitivity, PPV and cure rate were retained. Quality of included studies was assessed using the QUADAS-2 Tool. Patient-based sensitivity, PPV and cure rate were pooled by using a random-effects model. EVIDENCE SYNTHESIS: Twenty-three studies including 1716 patients were included for quantitative assessment. FCH PET showed a pooled patient-based sensitivity of 93.8% (95% CI: 89.8-96.3) and PPV of 97% (95% CI: 92.8-98.8) in patients with pHPT. Parathyroid surgery was performed in 1129 patients. The pooled cure rate of PET-guided surgery was 92.8% (95% CI: 87.4-96.0). Heterogeneity was shown to be moderate for all effect sizes. CONCLUSIONS: FCH PET showed a high patient-based sensitivity, PPV and cure rate of PET guided surgery in patients with pHPT.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Elske Quak"
    },
    {
      "name": "Marie Cavarec"
    },
    {
      "name": "Renaud Ciappuccini"
    },
    {
      "name": "Gilles Girault"
    },
    {
      "name": "Roman Rouzier"
    },
    {
      "name": "Justine Lequesne"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6c48746k3etqs.bib",
  "cited_by": 31,
  "doi": "10.23736/s1824-4785.23.03512-4",
  "fulltext_url": null,
  "id": "6c48746k3etqs",
  "issns": [
    "1824-4785"
  ],
  "landing_url": "https://hal.science/hal-05744796v1",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.sdv"
    ],
    [
      "hal",
      "0.shs"
    ],
    [
      "openalex",
      "2746|Thyroid and Parathyroid Surgery"
    ]
  ],
  "openalex": "W4319656136",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-10",
  "publisher": "Edizioni Minerva Medica",
  "ris": "https://research.draconitic.com/paper/6c48746k3etqs.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:33Z",
      "native_id": "hal-05744796",
      "source": "hal",
      "url": "https://hal.science/hal-05744796v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Thyroid and Parathyroid Surgery",
      "subfield": "surgery"
    }
  ],
  "title": "Detection, resection and cure: a systematic review and meta-analysis of 18F-choline PET in primary hyperparathyroidism",
  "title_text": "Detection, resection and cure: a systematic review and meta-analysis of 18F-choline PET in primary hyperparathyroidism",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:33Z",
  "url": "https://research.draconitic.com/paper/6c48746k3etqs",
  "venue": "The quarterly journal of nuclear medicine and molecular imaging",
  "versions": []
}