{
  "abstract": "Background Extracellular Vesicles (EVs) play an important role in cell communication, signal transduction, and the modulation of metabolic processes. The current study aimed to evaluate the effects of Echinococcus granulosus hydatid cyst fluid (HCF) and its EVs on serotonin receptors liver cell line. Results The expression level of 5-HT2A receptor gene showed significant increase in EVs and HCF treated cells after 24 h, 1.73 (p < 0.0001) and 1.62 (p = 0.0084), and 48 h, 1.39 (p = 0.0069), 1.66 (p = 0.0034) respectively. A significant decrease in expression of 5-HT2B receptor gene was seen in the EVs and the HCF group during the first 24 h, p < 0.0001 (EVs: -6.33, HCF: -1.84), while this downregulation in EVs-treated cells was decreased after 48 h (-1.94; p < 0.0001). Furthermore, the gene expression of the liver enzymes, aspartate transaminase (AST) and alanine transaminase (ALT), was significantly changed in both HCF and EVs groups. Conclusion The findings indicate that HCF and its EVs may alter serotonin receptors gene expression. These results suggest that HCF and its EVs may modulate the fibrosis pathways through decreasing the expression of 5-HT2B receptor.",
  "abstract_shown": true,
  "affiliations": [
    "Student Research Committee, Department of Medical Parasitology and Mycology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences",
    "Department of Medical Parasitology and Mycology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences",
    "Department of Medical Parasitology and Mycology, school of Medicine, Urmia University of Medical Sciences",
    "Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR",
    "Research Center for Hydatid Disease in Iran, Department of Parasitology, Afzalipour School of Medicine, Kerman University of Medical Sciences",
    "Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Leyli Zanjirani Farahani"
    },
    {
      "affs": [
        1
      ],
      "name": "Soheila Rouhani"
    },
    {
      "affs": [
        2
      ],
      "name": "Fatemeh Mahdavi"
    },
    {
      "affs": [
        1
      ],
      "name": "Maryam Niyyati"
    },
    {
      "affs": [
        3
      ],
      "name": "Nasim Eslami"
    },
    {
      "affs": [
        4
      ],
      "name": "Majid Fasihi Harandi"
    },
    {
      "affs": [
        5
      ],
      "name": "Hamed Mirjalali"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6cd379f0ts64d.bib",
  "cited_by": 0,
  "doi": "10.1186/s12866-026-05454-1",
  "fulltext_url": "https://doi.org/10.1186/s12866-026-05454-1",
  "id": "6cd379f0ts64d",
  "issns": [
    "1471-2180"
  ],
  "landing_url": "https://doi.org/10.1186/s12866-026-05454-1",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QR1-502"
    ],
    [
      "openalex",
      "2734|Parasitic infections in humans and animals"
    ]
  ],
  "openalex": "W7171427143",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-01",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/6cd379f0ts64d.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:50Z",
      "native_id": "f30c399c544340fea9a63f27822cc4ca",
      "source": "doaj",
      "url": "https://doi.org/10.1186/s12866-026-05454-1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "lcc:QR1-502",
      "subfield": "microbiology"
    }
  ],
  "title": "Extracellular vesicles derived from Echinococcus granulosus hydatid cyst fluid may modulate liver fibrosis through 5-HT2B receptor",
  "title_text": "Extracellular vesicles derived from Echinococcus granulosus hydatid cyst fluid may modulate liver fibrosis through 5-HT2B receptor",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:50Z",
  "url": "https://research.draconitic.com/paper/6cd379f0ts64d",
  "venue": "BMC Microbiology",
  "versions": []
}