{
  "abstract": "Gene therapies are at the forefront of potential treatments for cardiovascular diseases, but clinical translation remains limited by poor myocardial access and retention, systemic distribution, and immune-mediated toxicities. Heavily underexplored, the route of administration dictates efficacy and safety, ultimately influencing therapeutic outcomes. This review addresses the role of delivery in overcoming these challenges in cardiac adeno-associated viral therapies. Emphasis is placed on biomaterial-based delivery approaches to improve therapeutic outcomes.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Engineering in Medicine,Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.",
    "Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA, USA.",
    "Department of Surgery, Emory University, Atlanta, GA, USA.",
    "Department of Pediatrics, Aflac Cancer and Blood Disorders Center, Emory University and Children's Healthcare of Atlanta, Atlanta, GA, USA.",
    "Division of Engineering in Medicine,Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. rlevit@emory.edu."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gabriella Kabboul"
    },
    {
      "affs": [
        1
      ],
      "name": "Alejandro Izurieta Muñoz"
    },
    {
      "affs": [
        2
      ],
      "name": "Muath Bishawi"
    },
    {
      "affs": [
        3
      ],
      "name": "Christopher B Doering",
      "orcid": "0000-0002-5662-0060"
    },
    {
      "affs": [
        4
      ],
      "name": "Rebecca D Levit"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6cr7t4r8s938m.bib",
  "cited_by": 0,
  "doi": "10.1038/s44385-026-00117-2",
  "fulltext_url": "https://europepmc.org/articles/PMC13728188",
  "id": "6cr7t4r8s938m",
  "issns": [
    "3005-1444"
  ],
  "landing_url": "https://europepmc.org/article/MED/42972024",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "1311|Virus-based gene therapy research"
    ]
  ],
  "openalex": "W7225073308",
  "pdf_url": "https://europepmc.org/articles/PMC13728188?pdf=render",
  "pmcid": "PMC13728188",
  "pmid": "42972024",
  "published": "2026-11-02",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/6cr7t4r8s938m.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:43Z",
      "native_id": "MED:42972024",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42972024"
    },
    {
      "first_seen": "2026-11-06T12:23:55Z",
      "native_id": "PMC13728188",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s44385-026-00117-2"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Virus-based gene therapy research",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Challenges and innovations in cardiac AAV gene delivery as a platform for cardiac regeneration.",
  "title_text": "Challenges and innovations in cardiac AAV gene delivery as a platform for cardiac regeneration.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:21:13Z",
  "url": "https://research.draconitic.com/paper/6cr7t4r8s938m",
  "venue": "Npj biomedical innovations",
  "versions": []
}