{
  "abstract": "Aberrant aggregation of the transactive response DNA-binding protein (TDP-43) is associated with several lethal neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal dementia. Cytoplasmic neuronal inclusions of TDP-43 are enriched in various fragments of the low-complexity C-terminal domain and are associated with different neurotoxicity. Here we dissect the structural basis of TDP-43 polymorphism using magic-angle spinning solid-state NMR spectroscopy in combination with electron microscopy and Fourier-transform infrared spectroscopy. We demonstrate that various low-complexity C-terminal fragments, namely TDP-13 (TDP-43 300–414 ), TDP-11 (TDP-43 300–399 ), and TDP-10 (TDP-43 314–414 ), adopt distinct polymorphic structures in their amyloid fibrillar state. Our work demonstrates that the removal of less than 10% of the low-complexity sequence at N- and C-termini generates amyloid fibrils with comparable macroscopic features but different local structural arrangement. It highlights that the assembly mechanism of TDP-43, in addition to the aggregation of the hydrophobic region, is also driven by complex interactions involving low-complexity aggregation-prone segments that are a potential source of structural polymorphism.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Sonia Landro"
    },
    {
      "name": "Ransford Parry"
    },
    {
      "name": "Isabella Gutiérrez-Zabala"
    },
    {
      "name": "Nagore González-Soto"
    },
    {
      "name": "Sophie Lecomte"
    },
    {
      "name": "Eider Bilbao"
    },
    {
      "name": "Florencia Arrighetti"
    },
    {
      "name": "Miren Cajaraville"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6cv9z5swbdhb4.bib",
  "cited_by": 0,
  "doi": "10.1016/j.marpolbul.2026.119615",
  "fulltext_url": null,
  "id": "6cv9z5swbdhb4",
  "issns": [
    "0025-326X",
    "1879-3363"
  ],
  "landing_url": "https://hal.science/hal-05842086v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "0.sde"
    ],
    [
      "openalex",
      "2307|Environmental Toxicology and Ecotoxicology"
    ]
  ],
  "openalex": "W7143345969",
  "pdf_url": "https://hal.science/hal-05842086/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/6cv9z5swbdhb4.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:03Z",
      "native_id": "hal-05842086",
      "source": "hal",
      "url": "https://hal.science/hal-05842086v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "hal:0.chim",
      "subfield": "general"
    },
    {
      "field": "earth",
      "origin": "hal:0.sde",
      "subfield": "environmental-science"
    }
  ],
  "title": "Anthropogenic particles and legacy pollutants combined with transcriptomic and multi-biomarker responses for an integrated assessment of the health status of mussels Mytilus galloprovincialis in two locations of the Bay of Biscay",
  "title_text": "Anthropogenic particles and legacy pollutants combined with transcriptomic and multi-biomarker responses for an integrated assessment of the health status of mussels Mytilus galloprovincialis in two locations of the Bay of Biscay",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:20:56Z",
  "url": "https://research.draconitic.com/paper/6cv9z5swbdhb4",
  "venue": "Marine Pollution Bulletin",
  "versions": []
}