{
  "abstract": "Introduction This analysis evaluated the impact of early intraretinal fluid (IRF) reduction on long-term visual outcomes in patients with diabetic macular edema (DME). Methods This was a treatment-agnostic, post hoc analysis of pooled data from patients with DME in YOSEMITE/RHINE (NCT03622580/NCT03622593). The relationship between IRF volume changes (evaluated using deep learning-based retinal optical coherence tomography segmentation algorithm [ROSA]) after 3-monthly injections and anatomical/visual outcomes at 2 years was assessed. Patients were categorized by proportional IRF volume reduction from baseline at month 3: < 20% (group 1), 20–50% (group 2), > 50% (group 3). Comparisons were made across groups, including changes from baseline in ROSA-derived fluid volume and best-corrected visual acuity (BCVA). A complementary analysis was performed based on IRF volume reduction at 1-month and 1-year outcomes. Results The main analysis included eyes from 795 patients: 259 (32.6%) treated with faricimab 6 mg every 8 weeks (Q8W), 279 (35.1%) treated with faricimab 6 mg treat-and-extend, and 257 (32.3%) treated with aflibercept 2 mg Q8W. In groups 1–3, mean IRF volume decreases from baseline at year 2 were 236, 282, and 312 nL (nominal p < 0.05 for groups 2 and 3 vs. 1), respectively. Corresponding subretinal fluid volume decreases were 37, 48, and 41 nL, respectively. In groups 1–3, adjusted mean BCVA increases from baseline at year 2 were 7.9, 10.3, and 12.2 letters (nominal p = 0.0005 for group 1 vs. 3), respectively, with 23%, 36%, and 41% of patients (nominal p = 0.0015 for group 1 vs. 3), respectively, gaining ≥ 15 letters. Similar results were observed in the complementary analysis. Conclusion Greater IRF volume reduction during the first 3 months of treatment was associated with improved long-term outcomes in DME. These data may inform discussions between physicians and their patients when discussing long-term anatomic/functional outcomes of treatment. Trial Registration ClinicalTrials.gov identifier: NCT03622580/NCT03622593 (YOSEMITE/RHINE).",
  "abstract_shown": true,
  "affiliations": [
    "Genentech, Inc.",
    "Doheny Eye Institute",
    "University of Illinois at Chicago",
    "Desert Retina Consultants",
    "Singapore National Eye Centre",
    "Cleveland Clinic",
    "Roche Products Ltd.",
    "F. Hoffmann-La Roche Ltd."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yiyi Wang"
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    {
      "affs": [
        0
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      "name": "Derrek P. Hibar"
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        1
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      "name": "Srinivas Sadda"
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        2
      ],
      "name": "Jennifer I. Lim"
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    {
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        3
      ],
      "name": "Clement K. Chan"
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    {
      "affs": [
        4
      ],
      "name": "Gavin S. Tan"
    },
    {
      "affs": [
        5
      ],
      "name": "Katherine E. Talcott"
    },
    {
      "affs": [
        6
      ],
      "name": "Kara Gibson"
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    {
      "affs": [
        7
      ],
      "name": "Andreas Maunz"
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    {
      "affs": [
        7
      ],
      "name": "Huanxiang Lu"
    },
    {
      "affs": [
        7
      ],
      "name": "Thomas Albrecht"
    },
    {
      "affs": [
        0
      ],
      "name": "Manuel Amador"
    },
    {
      "affs": [
        0
      ],
      "name": "Katie M. Litts"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6d3gmw1yz1tdb.bib",
  "cited_by": 0,
  "doi": "10.1007/s40123-026-01504-z",
  "fulltext_url": "https://doi.org/10.1007/s40123-026-01504-z",
  "id": "6d3gmw1yz1tdb",
  "issns": [
    "2193-8245",
    "2193-6528"
  ],
  "landing_url": "https://doi.org/10.1007/s40123-026-01504-z",
  "language": "en",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
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    [
      "lcc",
      "RE1-994"
    ],
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      "2731|Retinal Diseases and Treatments"
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  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s40123-026-01504-z.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-01",
  "publisher": "Adis, Springer Healthcare",
  "ris": "https://research.draconitic.com/paper/6d3gmw1yz1tdb.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:45:48Z",
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  "subjects": [
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  "title": "Early Intraretinal Fluid Reduction is Linked to Vision Gains in Patients with Diabetic Macular Edema",
  "title_text": "Early Intraretinal Fluid Reduction is Linked to Vision Gains in Patients with Diabetic Macular Edema",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:45:48Z",
  "url": "https://research.draconitic.com/paper/6d3gmw1yz1tdb",
  "venue": "Ophthalmology and Therapy",
  "versions": []
}