{
  "abstract": "Crohn’s disease (CD) is a chronic inflammatory bowel disease characterized by a heterogeneous clinical course and the potential development of irreversible bowel damage. Its therapeutic landscape has evolved substantially with the introduction of biologics and small molecules that target diverse inflammatory pathways, as well as new formulations and biosimilars of established biologics. These advances have expanded treatment options and enabled more ambitious therapeutic goals beyond symptomatic improvement, including corticosteroid-free remission, endoscopic healing, and prevention of disease progression. However, selecting and positioning therapies remain challenging because of differences in disease severity and phenotype, prior treatment exposure, safety considerations, patient preferences, and limited evidence from direct comparative studies. Additionally, important uncertainties remain regarding combination therapy with immunomodulators, treatment de-escalation, switching between originators and biosimilars, and management of perianal fistulizing disease. To provide evidence-based and clinically applicable recommendations, the Korean Association for the Study of Intestinal Diseases developed updated clinical practice guidelines for the medical management of adult patients with CD. This guideline was developed using a GRADE-ADOLOPMENT approach that combined the adaptation of high-quality existing guidelines with de novo development based on newly identified evidence. The certainty of the evidence and strength of the recommendations were assessed using the Grading of Recommendations Assessment, Development and Evaluation approach. The guideline addresses conventional therapies, immunomodulators, biologics, small molecules, biosimilars, alternative formulations, combination and de-escalation strategies, and perianal fistulizing disease. These recommendations are intended to support individualized therapeutic decision-making and improve the quality of care for adult patients with CD.",
  "abstract_shown": true,
  "affiliations": [
    "중앙대학교 의과대학 내과학교실",
    "대구가톨릭대학교 의과대학 내과학교실",
    "전남대학교 의과대학 내과학교실",
    "부산대학교 의과대학 내과학교실",
    "부산대학교병원 소화기내과",
    "부산대학교병원 의생명연구원",
    "이화여자대학교 의과대학 내과학교실",
    "성균관대학교 의과대학 삼성서울병원 내과학교실",
    "한림대학교 의과대학 춘천성심병원 내과학교실",
    "한림대학교 의과대학 강동성심병원 내과학교실",
    "가톨릭대학교 의과대학 대전성모병원 내과학교실",
    "경북대학교 의과대학 내과학교실",
    "조선대학교 의과대학 내과학교실",
    "가톨릭대학교 의과대학 인천성모병원 내과학교실",
    "연세대학교 의과대학 내과학교실 및 소화기병연구소",
    "울산대학교 의과대학 서울아산병원 소화기내과",
    "연세대학교 원주의과대학 원주의학도서관",
    "한국보건의료연구원",
    "울산대학교 의과대학 서울아산병원 외과 대장항문외과"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 23,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "승용 신"
    },
    {
      "affs": [
        1
      ],
      "name": "준화 배"
    },
    {
      "affs": [
        2
      ],
      "name": "동현 김"
    },
    {
      "affs": [
        3
      ],
      "name": "승민 홍"
    },
    {
      "affs": [
        4
      ],
      "name": "은미 송"
    },
    {
      "affs": [
        5
      ],
      "name": "지은 김"
    },
    {
      "affs": [
        6
      ],
      "name": "영주 양"
    },
    {
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        7
      ],
      "name": "지영 윤"
    },
    {
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        8
      ],
      "name": "상범 강"
    },
    {
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      ],
      "name": "은수 김"
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        4
      ],
      "name": "성은 김"
    },
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        10
      ],
      "name": "성중 김"
    },
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        10
      ],
      "name": "준 이"
    },
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        11
      ],
      "name": "수영 나"
    },
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      ],
      "name": "수정 박"
    },
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      ],
      "name": "상형 박"
    },
    {
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        14
      ],
      "name": "명하 김"
    },
    {
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        15
      ],
      "name": "미영 최"
    },
    {
      "affs": [
        16
      ],
      "name": "종률 이"
    },
    {
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        17
      ],
      "name": "세진 백"
    },
    {
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        18
      ],
      "name": "원 문",
      "orcid": "0000-0002-3963-8680"
    },
    {
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        4
      ],
      "name": "성애 정",
      "orcid": "0000-0002-3963-8680"
    },
    {
      "name": "대한장연구학회 가이드라인위원회"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6dc867hz0r2a7.bib",
  "cited_by": 0,
  "doi": "10.4166/kjg.2026.092",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13714430/",
  "id": "6dc867hz0r2a7",
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    "1598-9992",
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  "landing_url": "https://doi.org/10.4166/kjg.2026.092",
  "language": "ko",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Lower GI Tract"
    ],
    [
      "heading",
      "REVIEW ARTICLE"
    ],
    [
      "openalex",
      "1311|Inflammatory Bowel Disease"
    ]
  ],
  "openalex": "W7223576973",
  "pdf_url": "https://www.kjg.or.kr/journal/download_pdf.php?doi=10.4166/kjg.2026.092",
  "pmcid": "PMC13714430",
  "pmid": "42928005",
  "published": "2026-10-25",
  "publisher": "Korean Society of Gastroenterology",
  "ris": "https://research.draconitic.com/paper/6dc867hz0r2a7.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:21:55Z",
      "native_id": "PMC13714430",
      "source": "pmc",
      "url": "https://doi.org/10.4166/kjg.2026.092"
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Inflammatory Bowel Disease",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "2026 대한장연구학회 크론병 내과적 치료 가이드라인",
  "title_text": "2026 대한장연구학회 크론병 내과적 치료 가이드라인",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:55Z",
  "url": "https://research.draconitic.com/paper/6dc867hz0r2a7",
  "venue": "The Korean Journal of Gastroenterology",
  "versions": []
}