{
  "abstract": "Herein, we report that stabilized phosphorus ylides can serve as formal carbyne precursors for selective one-carbon insertion into indenes, affording naphthalenes under photoredox/cobalt dual catalysis. Compared with commonly employed α-iodonium diazo carbyne precursors, phosphorus ylides represent a safe and practical alternative. This protocol exhibits excellent functional-group tolerance, furnishing a diverse array of naphthalenes incorporating trifluoromethyl, cyano, iodo, and olefin moieties, as well as various heterocycles (e.g., furan, thiophene, thiazole, and benzothiophene). The good compatibility of the protocol is also demonstrated via the late-stage modification of drug-like molecules. Finally, a mechanism involving a cyclopropane radical intermediate and a hydrogen atom transfer (HAT)-induced aromatization process was proposed.",
  "abstract_shown": true,
  "affiliations": [
    "Jiangxi Provincial Key Laboratory of Organic Functional Molecules, Institute of Organic Chemistry, Jiangxi Science and Technology Normal University Nanchang 330013 P.R. China",
    "The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, School of Pharmacy, Jiangxi Medical College, Nanchang University Nanchang 330006 P. R. China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jia Song"
    },
    {
      "affs": [
        0
      ],
      "name": "Wei-Wei Cheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Xian-Rong Song",
      "orcid": "0000-0002-8547-7881"
    },
    {
      "affs": [
        1
      ],
      "name": "Yong-Qin He",
      "orcid": "0000-0003-3996-0466"
    },
    {
      "affs": [
        0
      ],
      "name": "Wan-Fa Tian",
      "orcid": "0000-0003-1873-5366"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiang Xiao",
      "orcid": "0000-0003-2812-7778"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6dh9t5r15f8cr.bib",
  "cited_by": 0,
  "doi": "10.1039/d6sc06407h",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13735226/",
  "id": "6dh9t5r15f8cr",
  "issns": [
    "2041-6520",
    "2041-6539"
  ],
  "landing_url": "https://doi.org/10.1039/d6sc06407h",
  "language": "en",
  "licence": "CC-BY-3.0",
  "licence_label": "CC BY 3.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/3.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Chemistry"
    ],
    [
      "openalex",
      "1605|Cyclopropane Reaction Mechanisms"
    ]
  ],
  "openalex": "W7221020721",
  "pdf_url": "https://pubs.rsc.org/sc/article-pdf/doi/10.1039/D6SC06407H/14855679/d6sc06407h.pdf",
  "pmcid": "PMC13735226",
  "pmid": "42991166",
  "published": "2026-10-08",
  "publisher": "Royal Society of Chemistry",
  "ris": "https://research.draconitic.com/paper/6dh9t5r15f8cr.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:20:56Z",
      "native_id": "PMC13735226",
      "source": "pmc",
      "url": "https://doi.org/10.1039/d6sc06407h"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Cyclopropane Reaction Mechanisms",
      "subfield": "organic"
    }
  ],
  "title": "Harnessing carbyne reactivity from stabilized phosphorus ylides: the skeletal editing of indenes via single-carbon insertion",
  "title_text": "Harnessing carbyne reactivity from stabilized phosphorus ylides: the skeletal editing of indenes via single-carbon insertion",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:20:56Z",
  "url": "https://research.draconitic.com/paper/6dh9t5r15f8cr",
  "venue": "Chemical Science",
  "versions": []
}