{
  "abstract": "Negative pressure wound therapy with instillation and dwell time (NPWTi-d) and conventional NPWT are established treatments for complex wounds, yet direct comparative evidence remains limited. This retrospective observational study evaluated the clinical effectiveness of NPWTi-d for hard-to-heal necrotic wounds using standardized parameters from our previous research. We included 116 patients (50 NPWTi-d; 66 conventional NPWT). The primary endpoint was the time from therapy initiation to achieving a 'reference wound' suitable for definitive closure, defined in accordance with clinical trial guidance from the Japanese Pharmaceuticals and Medical Devices Agency (PMDA). The NPWTi-d group achieved reference wound status in a median of 14 days versus 22 days for the conventional NPWT group-a statistically significant 8-day reduction. Furthermore, whereas conventional NPWT typically requires a prolonged debridement phase prior to application, NPWTi-d can be initiated earlier, even in the presence of residual necrotic tissue. Ultimately, NPWTi-d provides a synergistic clinical advantage by both shortening active treatment duration and bypassing pre-initiation delays, enabling clinicians to achieve surgical readiness significantly faster than with standard modalities.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Plastic Surgery, Kyorin University School of Medicine, Mitaka, Tokyo, Japan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Norihiko Ohura",
      "orcid": "0000-0002-1139-9307"
    },
    {
      "affs": [
        0
      ],
      "name": "Daisuke Nakayama"
    },
    {
      "affs": [
        0
      ],
      "name": "Mikio Kinoshita"
    },
    {
      "affs": [
        0
      ],
      "name": "Tomohide Shiraishi"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuki Morishige"
    },
    {
      "affs": [
        0
      ],
      "name": "Shungo Murai"
    },
    {
      "affs": [
        0
      ],
      "name": "Mine Ozaki",
      "orcid": "0000-0002-5342-7599"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6dhpnwgf9tjd4.bib",
  "cited_by": 0,
  "doi": "10.1111/iwj.71079",
  "fulltext_url": "https://europepmc.org/articles/PMC13716931",
  "id": "6dhpnwgf9tjd4",
  "issns": [
    "1742-4801",
    "1742-481X"
  ],
  "landing_url": "https://europepmc.org/article/MED/42952033",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7224299318",
  "pdf_url": "https://europepmc.org/articles/PMC13716931?pdf=render",
  "pmcid": "PMC13716931",
  "pmid": "42952033",
  "published": "2026-10-28",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/6dhpnwgf9tjd4.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:33Z",
      "native_id": "MED:42952033",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42952033"
    },
    {
      "first_seen": "2026-11-02T12:21:20Z",
      "native_id": "PMC13716931",
      "source": "pmc",
      "url": "https://doi.org/10.1111/iwj.71079"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Accelerated Preoperative Wound Bed Preparation Using Negative Pressure Wound Therapy With Instillation and Dwell Time: A Comparison With Conventional Negative Pressure Wound Therapy in Necrotic Wounds.",
  "title_text": "Accelerated Preoperative Wound Bed Preparation Using Negative Pressure Wound Therapy With Instillation and Dwell Time: A Comparison With Conventional Negative Pressure Wound Therapy in Necrotic Wounds.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:20Z",
  "url": "https://research.draconitic.com/paper/6dhpnwgf9tjd4",
  "venue": "International wound journal",
  "versions": []
}