{
  "abstract": "Carbon–hydrogen (C–H) functionalization methodologies typically rely on electron-poor π-systems, whereas the engagement of electron-rich counterparts remains underdeveloped. Herein, we report the first cobalt-catalyzed, site- and regioselective C–H functionalization of O-phenyl hydroxamic acids with electron-rich ynamides to afford aminoisoquinolones and 2-pyridones. Combined experimental and computational mechanistic studies reveal a pathway governed by Curtin–Hammett kinetics, featuring reversible concerted metalation deprotonation, irreversible selectivitydetermining migratory insertion, and turnover-limiting C–N reductive elimination. The transformation proceeds via divergent pathways, wherein the major 4-aminoisoquinolone is generated through a Co(III) cycle and the minor 3aminoisoquinolone transits a Co(III)/Co(I) redox manifold. Furthermore, high-valent Co(V) nitrenoids, which are frequently invoked in related reactions, are ruled out as catalytic intermediates.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Yujie Cao"
    },
    {
      "name": "Justin D. DeBow"
    },
    {
      "name": "Elise Mach"
    },
    {
      "name": "Melody Wu"
    },
    {
      "name": "Veronica Carta"
    },
    {
      "name": "Kevin G. M. Kou",
      "orcid": "0000-0002-4676-8846"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6dpzzfh1cm0fx.bib",
  "cited_by": 0,
  "doi": "10.26434/chemrxiv.15009358/v1",
  "fulltext_url": null,
  "id": "6dpzzfh1cm0fx",
  "issns": [],
  "landing_url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009358/v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Catalytic C–H Functionalization Methods"
    ]
  ],
  "openalex": "W7214128756",
  "pdf_url": "https://chemrxiv.org/doi/pdf/10.26434/chemrxiv.15009358/v1",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-23",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/6dpzzfh1cm0fx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:21Z",
      "native_id": "10.26434/chemrxiv.15009358",
      "source": "chemrxiv",
      "url": "https://chemrxiv.org/doi/full/10.26434/chemrxiv.15009358/v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Catalytic C–H Functionalization Methods",
      "subfield": "organic"
    }
  ],
  "title": "Cobalt(III)-Catalyzed Synthesis of Aminoisoquinolones and Amino-2-Pyridones via C–H Functionalization with Ynamides: A Combined Experimental and Computational Study",
  "title_text": "Cobalt(III)-Catalyzed Synthesis of Aminoisoquinolones and Amino-2-Pyridones via C–H Functionalization with Ynamides: A Combined Experimental and Computational Study",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:21Z",
  "url": "https://research.draconitic.com/paper/6dpzzfh1cm0fx",
  "venue": "ChemRxiv",
  "versions": []
}