{
  "abstract": "Purpose of Review: Arrhythmia-induced cardiomyopathy (AIC) is an increasingly recognized and potentially reversible cause or modifier of heart failure. This review summarizes experimental and clinical evidence with a focus on atrial fibrillation (AFib)-induced left ventricular systolic dysfunction.\n\nRecent Findings: Recent studies demonstrate that AIC extends beyond tachycardia alone and involves rhythm irregularity, loss of atrioventricular synchrony, altered calcium handling, oxidative stress, mitochondrial dysfunction and substrate vulnerability. Clinical trials demonstrate the superiority of rhythm control therapy by catheter ablation in patients with AFib and heart failure. Emerging data illustrate the importance of phenotyping of AIC according to myocardial substrate and individual ventricular response to AFib.\n\nSummary: AIC should be considered as a heterogeneous spectrum. Refined phenotyping may improve prediction of recovery and guide specific and individual therapy.",
  "abstract_shown": true,
  "affiliations": [
    "Medical Clinic I, Cardiology and Angiology, University Hospital of Giessen and Marburg, Giessen, Germany",
    "Institute for Experimental and Translational Cardiology, Justus-Liebig-Universität Giessen, Giessen, Germany",
    "Department of Cardiology at Kerckhoff Heart and Lung Center, Bad Nauheim, Germany",
    "Excellence Cluster Cardiopulmonary Institute (CPI), Giessen, Germany"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Thomas Körtl"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Johannes Ruppert"
    },
    {
      "affs": [
        0,
        1,
        2,
        3
      ],
      "name": "Samuel Sossalla"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6dwdbsdgafy2d.bib",
  "cited_by": 0,
  "doi": "10.1007/s11897-026-00788-3",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13714119/",
  "id": "6dwdbsdgafy2d",
  "issns": [
    "1546-9530",
    "1546-9549"
  ],
  "landing_url": "https://doi.org/10.1007/s11897-026-00788-3",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2705|Atrial Fibrillation Management and Outcomes"
    ]
  ],
  "openalex": "W7223904336",
  "pdf_url": null,
  "pmcid": "PMC13714119",
  "pmid": "42944979",
  "published": "2026-10-27",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6dwdbsdgafy2d.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:21:40Z",
      "native_id": "PMC13714119",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s11897-026-00788-3"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Atrial Fibrillation Management and Outcomes",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Phenotyping of Arrhythmia-induced Cardiomyopathy: From Bench to Bedside and Back",
  "title_text": "Phenotyping of Arrhythmia-induced Cardiomyopathy: From Bench to Bedside and Back",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:21:40Z",
  "url": "https://research.draconitic.com/paper/6dwdbsdgafy2d",
  "venue": "Current Heart Failure Reports",
  "versions": []
}