{
  "abstract": "Background/Objectives: Contemporary stent retrievers differ in design, yet direct comparative evidence regarding their first-pass reperfusion performance using a standardized endpoint remains limited. This study compared first-pass reperfusion outcomes among APERIO, Trevo NXT, and EmboTrap III. Methods: In this exploratory, single-center retrospective cohort study, 200 patients were screened between 1 March 2024 and 1 August 2026. Forty patients had not completed 90-day follow-up at the time of the initial data analysis. An additional 104 patients were excluded because of tandem occlusion (n = 29), recanalization after intravenous thrombolysis before thrombectomy (n = 8), distal vessel occlusion (n = 30), or successful direct aspiration without stent-retriever deployment (n = 37). The final cohort comprised 56 patients treated with first-line combined stent-retriever and aspiration thrombectomy using APERIO (n = 28), Trevo NXT (n = 14), or EmboTrap III (n = 14). The primary endpoint was strict first-pass effect (FPE), defined as first-pass expanded Treatment in Cerebral Ischemia (eTICI) grade 2c–3. Results: Strict FPE was achieved in 16/28 (57.1%), 9/14 (64.3%), and 9/14 (64.3%) patients, respectively (global exact p = 0.879). Both comparisons with APERIO yielded an absolute risk difference of +7.1 percentage points (95% CI, −23.2 to +33.6). Exploratory adjusted analyses yielded imprecise estimates. Heidelberg-classified symptomatic intracranial hemorrhage occurred in zero, three, and two patients, respectively. Conclusions: No statistically detectable difference in strict FPE was demonstrated among the three device-based treatment strategies. However, the small sample size, wide confidence intervals, and nonrandomized treatment allocation preclude conclusions regarding device equivalence or causal effects.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Faculty of Medicine, Niğde Ömer Halisdemir University, Bor Yolu Üzeri, Central Campus, 51240 Niğde, Türkiye",
    "Department of Neurology, Niğde Ömer Halisdemir University Training and Research Hospital, Aşağı Kayabaşı Mahallesi, Hastaneler Caddesi, Kumluca Mevkii, 51100 Niğde, Türkiye"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 1,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Halil İbrahim Akçay",
      "orcid": "0000-0001-9973-2882"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6e0w9t6gd3d6y.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15218412",
  "fulltext_url": null,
  "id": "6e0w9t6gd3d6y",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/21/8412",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/6e0w9t6gd3d6y.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:01Z",
      "native_id": "10.3390/jcm15218412",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/21/8412"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "The RETRIAD Study: Comparative First-Pass Reperfusion Performance of EmboTrap III, Trevo NXT, and APERIO Stent Retrievers in Acute Large-Vessel Occlusion Stroke: A Single-Center Retrospective Cohort Study",
  "title_text": "The RETRIAD Study: Comparative First-Pass Reperfusion Performance of EmboTrap III, Trevo NXT, and APERIO Stent Retrievers in Acute Large-Vessel Occlusion Stroke: A Single-Center Retrospective Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T00:21:07Z",
  "url": "https://research.draconitic.com/paper/6e0w9t6gd3d6y",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}