{
  "abstract": "Objective\n\nTo describe the off-label intradermal use of ready-to-use liquid relabotulinumtoxinA (Relfydess) for symptomatic Frey's syndrome after parotidectomy.Methods\n\nA 72-year-old man with gustatory sweating and flushing after total parotidectomy and adjuvant radiotherapy, who had previously responded to conventional botulinum toxin A, underwent gustatory provocation, clinical mapping, and intradermal relabotulinumtoxinA injections using a 1-cm² grid. Clinical response and treatment-related adverse events were assessed at 6 weeks and 3 months.Results\n\nAt 6 weeks and 3 months, the patient reported symptom reduction comparable to his previous treatment with conventional botulinum toxin A. At 3 months, repeat gustatory stimulation elicited no visible sweating. No treatment-related adverse events were observed.Conclusion\n\nIn this patient, ready-to-use liquid relabotulinumtoxinA provided sustained symptom control for 3 months without observed adverse events. This formulation may offer a practical off-label option for previously responsive patients, while product-specific potency units should not be considered interchangeable.Level of evidence\n\n5.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Zurich Zurich Switzerland.",
    "University of Zurich Zurich Switzerland.",
    "Division of Phoniatrics and Speech Pathology, Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Zurich Zurich Switzerland."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Loris Zoller",
      "orcid": "0009-0002-6014-3700"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Philipp Reddiess"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Justus Müller-Goebel",
      "orcid": "0009-0003-9095-6312"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Tobias Kleinjung",
      "orcid": "0000-0003-3867-234X"
    },
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Daniel Runggaldier",
      "orcid": "0000-0003-2428-897X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6e89g5h5rqh5f.bib",
  "cited_by": 0,
  "doi": "10.1002/lio2.70618",
  "fulltext_url": "https://europepmc.org/articles/PMC13683557",
  "id": "6e89g5h5rqh5f",
  "issns": [
    "2378-8038"
  ],
  "landing_url": "https://europepmc.org/article/MED/42908782",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Sympathectomy and Hyperhidrosis Treatments"
    ]
  ],
  "openalex": "W7223134162",
  "pdf_url": "https://europepmc.org/articles/PMC13683557?pdf=render",
  "pmcid": "PMC13683557",
  "pmid": "42908782",
  "published": "2026-10-20",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6e89g5h5rqh5f.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:10Z",
      "native_id": "MED:42908782",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42908782"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Sympathectomy and Hyperhidrosis Treatments",
      "subfield": "physiology"
    }
  ],
  "title": "Treatment of Frey's Syndrome With \"Ready to Use Liquid\" Relabotulinumtoxin A (Relfydess).",
  "title_text": "Treatment of Frey's Syndrome With \"Ready to Use Liquid\" Relabotulinumtoxin A (Relfydess).",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:10Z",
  "url": "https://research.draconitic.com/paper/6e89g5h5rqh5f",
  "venue": "Laryngoscope investigative otolaryngology",
  "versions": []
}