{
  "abstract": "Background: Elevated high-sensitivity cardiac troponin T (hs-cTnT) is frequently observed in patients with acute ischemic stroke (AIS) and has been associated with adverse outcomes. We aimed to evaluate the association of admission hs-cTnT with 90-day functional outcome and all-cause mortality during follow-up, with particular attention to potential nonlinear risk patterns across the biomarker range.\n\nMethods: This single-center retrospective cohort study included 564 patients with AIS admitted between January 2022 and October 2024. The primary outcomes were modified Rankin Scale (mRS) at 90 days and long-term all-cause mortality. Multivariable logistic regression was used for poor 90-day functional outcome and Cox proportional hazards models were used for all-cause mortality during follow-up. Restricted cubic spline (RCS) analyses were performed to explore nonlinear dose–response relationships, and segmented regression models were used to estimate exploratory turning points.\n\nResults: Among 564 patients, 212 (37.6%) had elevated hs-cTnT (>14 ng/L). Elevated hs-cTnT was independently associated with poor 90-day mRS (adjusted OR 1.93, 95% CI, 1.22–3.05; p = 0.005) and all-cause mortality during follow-up (fully adjusted HR 4.12, 95% CI, 2.31–7.48; p < 0.001). During a median follow-up of 17 months (IQR 12–26 months), Kaplan–Meier analysis demonstrated significantly lower overall survival in patients with elevated hs-cTnT ( p < 0.001). RCS analysis revealed significant nonlinear associations between hs-cTnT and both endpoints ( p < 0.001). Exploratory model-derived turning points were observed at 28.42 ng/L for functional outcome and 31.68 ng/L for mortality; these should be interpreted as exploratory rather than validated clinical cutoffs. Below these values, risk increased more steeply; above them, no statistically significant further increase in risk was observed.\n\nConclusion: Admission hs-cTnT was independently associated with 90-day functional outcome and all-cause mortality during follow-up in patients with AIS. The association appeared to be nonlinear, with model-derived turning points at approximately 28–32 ng/L that should be interpreted as exploratory rather than definitive clinical cutoffs. Clinically, hs-cTnT may be useful as a complementary marker for identifying patients at higher risk who may warrant closer neuro-cardiac evaluation, although its incremental predictive value has not been formally assessed.",
  "abstract_shown": true,
  "affiliations": [
    "Shengli Clinical Medical College of Fujian Medical University",
    "Department of Neurology, Shanghang County Hospital",
    "Department of Neurology, Fuzhou University Affiliated Provincial Hospital"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yisheng Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Suhua Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Hua Xue"
    },
    {
      "affs": [
        0
      ],
      "name": "Rui Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Rongfang Wen"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhaoxiang Xiao"
    },
    {
      "affs": [
        1
      ],
      "name": "Xuerong Sheng"
    },
    {
      "affs": [
        1
      ],
      "name": "Peifeng Chen"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Na Song"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Yongkun Li"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6ed0njzqs4y6a.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1882492",
  "fulltext_url": null,
  "id": "6ed0njzqs4y6a",
  "issns": [
    "1664-2295"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1882492/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Acute Ischemic Stroke Management"
    ]
  ],
  "openalex": "W7223174472",
  "pdf_url": "https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1882492/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-22",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/6ed0njzqs4y6a.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:16Z",
      "native_id": "10.3389/fneur.2026.1882492",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1882492/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Acute Ischemic Stroke Management",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "Admission high-sensitivity cardiac troponin T and clinical outcomes after acute ischemic stroke: a retrospective cohort study with exploratory nonlinear analysis",
  "title_text": "Admission high-sensitivity cardiac troponin T and clinical outcomes after acute ischemic stroke: a retrospective cohort study with exploratory nonlinear analysis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:16Z",
  "url": "https://research.draconitic.com/paper/6ed0njzqs4y6a",
  "venue": "Frontiers in Neurology",
  "versions": []
}