{
  "abstract": "Chimeric antigen receptor T cell (CAR-T) has advanced rapidly in hematologic malignancies and even solid tumors, but post-treatment adverse reactions remain a major risk. Most adverse reactions are associated with inflammatory responses and cytokine release, such as cytokine release syndrome. Cytokine adsorption is an extracorporeal blood-purification approach designed to adsorb circulating inflammatory mediators. We report three patients with CAR-T-associated CRS, CRS with ICANS, or CRS with IEC-HS who received CA330-based cytokine adsorption as part of multimodal management. Clinical recovery and reductions in selected inflammatory markers were observed during the treatment course, and no procedure-related adverse events were documented. However, because adsorption overlapped with anti-IL-6 therapy, corticosteroids, anti-infective and supportive care, and the natural evolution of these toxicities, its independent contribution could not be determined. These observations support the feasibility of this approach and warrant prospective evaluation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Hematology, Shanghai Tongji Hospital, Tongji University School of Medicine",
    "Clinical Research Ward of Cancer Center, Shanghai Tongji Hospital, Tongji University School of Medicine",
    "Department of Nephrology, Shanghai Tongji Hospital, Tongji University School of Medicine"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Haoran Xu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Fangce Wang"
    },
    {
      "affs": [
        2
      ],
      "name": "Yuqiu Lu"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Wenjun Zhang"
    },
    {
      "affs": [
        2
      ],
      "name": "Yingying Zhang"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Aibin Liang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6eex2eaeg95e5.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1968648",
  "fulltext_url": null,
  "id": "6eex2eaeg95e5",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1968648/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-29",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/6eex2eaeg95e5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:17Z",
      "native_id": "10.3389/fimmu.2026.1968648",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1968648/full"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "issn:1664-3224",
      "subfield": "immunology"
    }
  ],
  "title": "Case Report: Cytokine adsorption during multimodal management of hyperinflammatory toxicities following CAR-T in three patients",
  "title_text": "Case Report: Cytokine adsorption during multimodal management of hyperinflammatory toxicities following CAR-T in three patients",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T00:20:59Z",
  "url": "https://research.draconitic.com/paper/6eex2eaeg95e5",
  "venue": "Frontiers in Immunology",
  "versions": []
}