{
  "abstract": "Macrophage lipophagy, the selective autophagic degradation of intracellular lipid droplets, plays a central role in maintaining lipid homeostasis and has emerged as a promising therapeutic target for atherosclerosis (AS). This review systematically synthesizes the classification, molecular mechanisms, and key signaling networks of macrophage lipophagy. Moreover, recent evidence on the anti-AS effects of Traditional Chinese Medicine (TCM) mediated by the regulation of macrophage lipophagy has also been summarized and evaluated, including active metabolites, medicinal plants, herbal formulas and commercial Chinese polyherbal preparations. Despite robust preclinical evidence, challenges remain. Significant efforts are still required to facilitate clinical translation and offer novel comprehensive strategies for the prevention and management of AS.",
  "abstract_shown": true,
  "affiliations": [
    "First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine",
    "Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital",
    "Guang’anmen Hospital of Chinese Academy of Traditional Chinese Medicine",
    "Tianjin University of Traditional Chinese Medicine"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
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        0
      ],
      "name": "Ying Hu"
    },
    {
      "affs": [
        1
      ],
      "name": "Shuo Yuan"
    },
    {
      "affs": [
        2
      ],
      "name": "Xingjuan Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu Wen"
    },
    {
      "affs": [
        0
      ],
      "name": "Fang Liu"
    },
    {
      "affs": [
        3
      ],
      "name": "Xuewei Dong"
    },
    {
      "affs": [
        3
      ],
      "name": "Mengxuan Cui"
    },
    {
      "affs": [
        0
      ],
      "name": "Na Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Hua Dong"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6ek8mmztay99p.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.1916672",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717145/?tool=EBI",
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  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.1916672/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
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  "native_subjects": [
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      "heading",
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  "pdf_url": "https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1916672/pdf",
  "pmcid": "PMC13717145",
  "pmid": "42959329",
  "published": "2026-10-15",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/6ek8mmztay99p.ris",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Autophagy in Disease and Therapy",
      "subfield": "epidemiology-public-health"
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  ],
  "title": "Macrophage lipophagy in atherosclerosis: from molecular mechanisms to traditional Chinese medicine interventions",
  "title_text": "Macrophage lipophagy in atherosclerosis: from molecular mechanisms to traditional Chinese medicine interventions",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:31Z",
  "url": "https://research.draconitic.com/paper/6ek8mmztay99p",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}