{
  "abstract": "Neuropathic pain (NP) remains a major clinical challenge as current medications are ineffective in treating the underlying cause, and the clinical use of these drugs also has adverse reactions such as addiction. Therefore, specialized pro-resolving mediators (SPMs) may represent a promising therapeutic strategy. Microglia-mediated neuroinflammation is central to NP pathogenesis, yet feasible strategies for precise modulation of microglial inflammatory responses remain limited. Here, we reveal that aspirin-triggered resolvin D1 (AT-RvD1) promotes a shift of microglia toward an anti-inflammatory and pro-repair state via a novel ANGPTL4-SUCLG1-propionate axis, consequently attenuating neuroinflammation and pain hypersensitivity in mice models with NP. To address invasive nature of intrathecal injection limitation in NP clinical treatment, an MG1 peptide-modified liposomal delivery system encapsulating AT-RvD1 (AT-RvD1@Lipo-MG1) is developed. Intravenous administration of this nanoplatform enables effective and targeted delivery of AT-RvD1 to spinal microglia, with robust analgesic and anti-inflammatory effects and favorable biosafety in vivo. This study elucidates a novel mechanism through which AT-RvD1 modulates microglial inflammatory responses and proposes a highly translatable nanotherapeutic strategy for the treatment of NP.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pain Management, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266000, China.",
    "Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266000, China.",
    "Tumor Immunology and Cytotherapy of Medical Research Center, Shandong Provincial Key Laboratory of Clinical Research for Pancreatic Diseases, the Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266000, China.",
    "Department of Obstetrics, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266000, China.",
    "Department of Spine Surgery, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266000, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Kaili Wu"
    },
    {
      "affs": [
        2
      ],
      "name": "Chao Gao"
    },
    {
      "affs": [
        2
      ],
      "name": "Shunli Fu"
    },
    {
      "affs": [
        3
      ],
      "name": "Yan Li"
    },
    {
      "affs": [
        4
      ],
      "name": "Zhaohui Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyi Han"
    },
    {
      "affs": [
        0
      ],
      "name": "Yun Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yingqi Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yihao Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6ew1v2htjmk4k.bib",
  "cited_by": 0,
  "doi": "10.1016/j.mtbio.2026.103726",
  "fulltext_url": "https://europepmc.org/articles/PMC13678001",
  "id": "6ew1v2htjmk4k",
  "issns": [
    "2590-0064"
  ],
  "landing_url": "https://europepmc.org/article/MED/42898631",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Pain Mechanisms and Treatments"
    ]
  ],
  "openalex": "W7220387232",
  "pdf_url": "https://europepmc.org/articles/PMC13678001?pdf=render",
  "pmcid": "PMC13678001",
  "pmid": "42898631",
  "published": "2026-10-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6ew1v2htjmk4k.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42898631",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42898631"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Pain Mechanisms and Treatments",
      "subfield": "physiology"
    }
  ],
  "title": "AT-RvD1 liposomes effectively accumulate in spinal cord and reprogram microglia via ANGPTL4-SUCLG1-propionate axis for treating neuropathic pain.",
  "title_text": "AT-RvD1 liposomes effectively accumulate in spinal cord and reprogram microglia via ANGPTL4-SUCLG1-propionate axis for treating neuropathic pain.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/6ew1v2htjmk4k",
  "venue": "Materials today. Bio",
  "versions": []
}