{
  "abstract": "Targeted alpha therapy will require a large expansion of ${}^{212}$Pb and ${}^{225}$Ac production. We propose neutron- and photon-driven routes that convert ${}^{230}$Th, ${}^{231}$Pa, ${}^{232}$Th, and ${}^{237}$Np into generator parents ${}^{228}$Th and ${}^{229}$Th. The most direct ${}^{225}$Ac route is ${}^{230}$Th(n,2n)${}^{229}$Th. A 10 MW deuterium-tritium (D-T) neutron source irradiating thorium with a 27% ${}^{230}$Th isotopic fraction accumulates about 250 Ci of ${}^{229}$Th in six months, initially enough for five million ${}^{225}$Ac dose-equivalents per year, and its 7916 yr half-life makes it useful for millennia. This requires only $\\sim$2 gigawatt-days of D-T fusion operations. Thermal-neutron irradiation of tens of grams of ${}^{230}$Th produces gram quantities of ${}^{232}$U, a decades-long source of ${}^{228}$Th for millions of ${}^{212}$Pb dose-equivalents per year. Alternate routes proceed through ${}^{231}$Pa: fusion neutrons produce 1 to 2 tonnes of ${}^{231}$Pa per gigawatt-year from ${}^{232}$Th, and a thermal reactor converts up to 0.4 g of ${}^{232}$U per gram of ${}^{231}$Pa. Each gram of stored ${}^{232}$U produces 10 mg (8.2 Ci) of ${}^{228}$Th per year. Subsequent ${}^{228}$Th(n,$γ$)${}^{229}$Th converts 0.07 to 0.34 g of ${}^{229}$Th per gram of ${}^{228}$Th. We also analyze the ${}^{237}$Np(n,2n)${}^{236\\mathrm{m}}$Np route to ${}^{228}$Th. These pathways scale from kilowatt to megawatt D-T sources and could secure millions of ${}^{212}$Pb and ${}^{225}$Ac dose-equivalents per year.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": "2609.19166",
  "author_total": 2,
  "authors": [
    {
      "name": "J. F. Parisi"
    },
    {
      "name": "A. Rutkowski"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6ewnh2rbb71bs.bib",
  "cited_by": 0,
  "doi": "10.48550/arxiv.2609.19166",
  "fulltext_url": null,
  "id": "6ewnh2rbb71bs",
  "issns": [],
  "landing_url": "https://arxiv.org/abs/2609.19166",
  "language": null,
  "licence": "LicenseRef-arXiv-nonexclusive-1.0",
  "licence_label": "arXiv licence",
  "licence_source": "article",
  "licence_url": "http://arxiv.org/licenses/nonexclusive-distrib/1.0/",
  "metadata_licence": "CC0-1.0",
  "native_subjects": [
    [
      "arxiv",
      "physics.plasm-ph"
    ],
    [
      "openalex",
      "2741|Radiopharmaceutical Chemistry and Applications"
    ]
  ],
  "openalex": "W7213594383",
  "pdf_url": "https://arxiv.org/pdf/2609.19166",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6ewnh2rbb71bs.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:19Z",
      "native_id": "2609.19166",
      "source": "arxiv",
      "url": "https://arxiv.org/abs/2609.19166"
    }
  ],
  "subjects": [
    {
      "field": "physics",
      "origin": "arxiv:physics.plasm-ph",
      "subfield": "plasma"
    }
  ],
  "title": "Scalable Production of Lead-212 and Actinium-225 Generators with Fusion Neutrons",
  "title_text": "Scalable Production of Lead-212 and Actinium-225 Generators with Fusion Neutrons",
  "type": "preprint",
  "updated_at": "2026-10-30T12:22:19Z",
  "url": "https://research.draconitic.com/paper/6ewnh2rbb71bs",
  "venue": "arXiv",
  "versions": []
}