{
  "abstract": "Amyloidosis is a disease characterized by the deposition of abnormally folded proteins as amyloid fibrils in tissues and occurs in various mammals and birds. In some cases, amyloids derived from two different precursor proteins may coexist in the same individual, a condition known as double amyloidosis. Amyloid A (AA) amyloidosis is known to occur frequently in birds; however, little is known about other types of amyloidosis. In the present study, we report a case of amyloidosis in a Humboldt penguin involving two distinct types of amyloids. Histopathological examination, transmission electron microscopy, mass spectrometry-based proteomic analysis, and immunohistochemistry revealed the concurrent occurrence of fibrinogen Aα-chain (FibA) amyloidosis and AA amyloidosis. FibA-derived and AA amyloid deposits exhibited distinct nodular and diffuse morphologies, respectively, suggesting that their deposition patterns may provide a morphological clue for distinguishing between the two types of amyloids. To our knowledge, this is the first case of FibA amyloidosis in a penguin and the first report of the concurrent occurrence of two distinct types of systemic amyloidosis in a bird.",
  "abstract_shown": true,
  "affiliations": [
    "Research Unit of Innovative One Medicine, Advanced Research Center for One Welfare, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai- cho, Fuchu, Tokyo, Japan. fq3733@go.tuat.ac.jp.",
    "Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Fuchu, Tokyo, Japan. fq3733@go.tuat.ac.jp.",
    "National Institute of Animal Health, National Agriculture and Food Research Organization, 3-1-5 Kannondai, Tsukuba, Ibaraki, Japan. fq3733@go.tuat.ac.jp.",
    "Laboratory of Veterinary Toxicology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Fuchu, Tokyo, Japan.",
    "Ibaraki Prefectural Kenpoku Livestock Hygiene Service Center, 966-1 Nakagachi-cho, Mito, Ibaraki, Japan.",
    "Smart-Core-Facility Promotion Organization, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo, Japan.",
    "National Institute of Animal Health, National Agriculture and Food Research Organization, 3-1-5 Kannondai, Tsukuba, Ibaraki, Japan.",
    "Department of Veterinary Immunology, Graduate School of Veterinary Medical Sciences, Osaka Metropolitan University, 1-58 Rinku- oraikita, Izumisano, Osaka, Japan.",
    "Hitachi Kamine Zoo, 5-2-22, Miyata-cho, Hitachi, Ibaraki, Japan."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Susumu Iwaide",
      "orcid": "0009-0005-0601-9137"
    },
    {
      "affs": [
        3
      ],
      "name": "Natsumi Kobayashi"
    },
    {
      "affs": [
        3
      ],
      "name": "Mako Ikudome"
    },
    {
      "affs": [
        4
      ],
      "name": "Shiho Takezawa"
    },
    {
      "affs": [
        5
      ],
      "name": "Yoshiyuki Itoh"
    },
    {
      "affs": [
        6,
        7
      ],
      "name": "Tomoyuki Shibahara"
    },
    {
      "affs": [
        8
      ],
      "name": "Keisuke Kawase"
    },
    {
      "affs": [
        3
      ],
      "name": "Tomoaki Murakami"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6fadh3hzfvjtc.bib",
  "cited_by": 0,
  "doi": "10.1007/s11259-026-11572-y",
  "fulltext_url": "https://europepmc.org/articles/PMC13653883",
  "id": "6fadh3hzfvjtc",
  "issns": [
    "0165-7380",
    "1573-7446"
  ],
  "landing_url": "https://europepmc.org/article/MED/42858211",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Amyloidosis: Diagnosis, Treatment, Outcomes"
    ]
  ],
  "openalex": "W7221329799",
  "pdf_url": "https://europepmc.org/articles/PMC13653883?pdf=render",
  "pmcid": "PMC13653883",
  "pmid": "42858211",
  "published": "2026-10-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6fadh3hzfvjtc.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "MED:42858211",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42858211"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Amyloidosis: Diagnosis, Treatment, Outcomes",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Concurrent fibrinogen Aα-chain amyloidosis and AA amyloidosis in a Humboldt penguin (Spheniscus humboldti).",
  "title_text": "Concurrent fibrinogen Aα-chain amyloidosis and AA amyloidosis in a Humboldt penguin (Spheniscus humboldti).",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/6fadh3hzfvjtc",
  "venue": "Veterinary research communications",
  "versions": []
}