{
  "abstract": "Background: Depression is a common psychiatric disorder associated with high recurrence rates and a substantial global disease burden. Although conventional antidepressant therapies remain the main treatment option, their clinical efficacy is often limited by delayed onset, inadequate brain targeting, systemic adverse effects, and considerable interindividual variability. These limitations highlight the need for more efficient drug delivery strategies for the central nervous system.\n\nMain body: Nanomedicine has emerged as a promising approach to improve antidepressant delivery and therapeutic efficacy. Nanocarriers can enhance drug solubility and stability, prolong systemic circulation, and facilitate transport across the blood–brain barrier (BBB), thereby increasing drug accumulation in the brain. Recent advances in nanotechnology-based drug delivery systems, including lipid-based nanocarriers and polymeric nanoparticles, have demonstrated potential for controlled drug release and targeted brain delivery while modulating key pathological processes involved in depression.\n\nConclusion: Overall, nanomedicine represents a promising strategy for improving the precision and effectiveness of antidepressant therapy, although further studies are required to address challenges related to biosafety, large-scale production, and clinical translation.\n\nGraphical Abstract:",
  "abstract_shown": true,
  "affiliations": [
    "Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China",
    "The Third Clinical Medical College, Zhejiang Chinese Medical University, 548 Binwen Road, Hangzhou, 310053 PR China",
    "Shulan International Medical College, Zhejiang Shuren University, 8 Shuren Street, Hangzhou, 310015 China"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xiaoyan Li"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Shilin Wen"
    },
    {
      "affs": [
        0
      ],
      "name": "Keer Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Sirun Lu"
    },
    {
      "affs": [
        0
      ],
      "name": "Ge Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Siyu Dai"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Minmin Jiang"
    },
    {
      "affs": [
        1
      ],
      "name": "Jianer Chen"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Xiao-Ling Xu",
      "orcid": "0000-0002-7472-0495"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6fn5affs54hkz.bib",
  "cited_by": 0,
  "doi": "10.1186/s12967-026-08811-w",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13737561/",
  "id": "6fn5affs54hkz",
  "issns": [
    "1479-5876"
  ],
  "landing_url": "https://doi.org/10.1186/s12967-026-08811-w",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7203785336",
  "pdf_url": null,
  "pmcid": "PMC13737561",
  "pmid": "42983547",
  "published": "2026-08-19",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/6fn5affs54hkz.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:22:42Z",
      "native_id": "PMC13737561",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12967-026-08811-w"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Tailoring nanoplatforms for depression applications",
  "title_text": "Tailoring nanoplatforms for depression applications",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:22:42Z",
  "url": "https://research.draconitic.com/paper/6fn5affs54hkz",
  "venue": "Journal of Translational Medicine",
  "versions": []
}