{
  "abstract": "High-frequency (~90-Hz) ripple oscillations may promote integrative processing in mammalian brains. Co-occurrence of ripple oscillations has been associated with enhanced temporal binding of neural activity between nearby human cortical neurons, but whether co-ripple facilitation of neuronal coupling supports cognitive processing or occurs at greater distances remains unclear. Here we analyze intracranial recordings from patients implanted with microwire electrodes in the hippocampus, amygdala, ventromedial prefrontal cortex, anterior cingulate cortex and pre-supplementary motor area, bilaterally, during a working memory task. We demonstrate that ripple rates increase in all recorded regions during encoding, maintenance and retrieval. Co-occurrence of ripples increases between brain regions, associated with ~30% increases in cross-region co-firing, without decrement over distances up to 220 mm. Cross-regional co-rippling and associated co-firing scale with memory load during maintenance and retrieval. During retrieval, co-ripples promote reinstatement of stimulus-specific, long-distance co-firing patterns observed during encoding, especially during rapid recognition. Co-occurring ripple oscillations thus coordinate long-range, stimulus-specific neural co-firing supporting distributed representations during human cognition.",
  "abstract_shown": true,
  "affiliations": [
    "Medical Scientist Training Program, University of California San Diego, La Jolla, CA, USA. iverzhbi@health.ucsd.edu",
    "Neurosciences Graduate Program, University of California San Diego, La Jolla, CA, USA. iverzhbi@health.ucsd.edu",
    "University of California - San Diego",
    "Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA",
    "Cedars Sinai Medical Center",
    "Center for Neural Science and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA",
    "Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, USA",
    "Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA",
    "University of California, San Diego",
    "Department of Neurosciences, University of California San Diego, La Jolla, CA, USA. ehalgren@health.ucsd.edu",
    "Department of Radiology, University of California San Diego, La Jolla, CA, USA. ehalgren@health.ucsd.edu"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Ilya A. Verzhbinsky",
      "orcid": "0000-0002-7890-8559"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Jonathan Daume",
      "orcid": "0000-0002-6516-7288"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Sophia Cheng",
      "orcid": "0009-0006-0799-2390"
    },
    {
      "affs": [
        5,
        6,
        3,
        7,
        8
      ],
      "name": "Ueli Rutishauser",
      "orcid": "0000-0002-9207-7069"
    },
    {
      "affs": [
        9,
        10
      ],
      "name": "Eric Halgren",
      "orcid": "0000-0001-5926-6872"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6fqbbpj4ystgc.bib",
  "cited_by": 7,
  "doi": "10.1038/s41593-026-02403-z",
  "fulltext_url": null,
  "id": "6fqbbpj4ystgc",
  "issns": [
    "1097-6256",
    "1546-1726"
  ],
  "landing_url": "https://doi.org/10.1038/s41593-026-02403-z",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2805|Neural dynamics and brain function"
    ]
  ],
  "openalex": "W4414045746",
  "pdf_url": null,
  "pmcid": "PMC12424764",
  "pmid": "40950034",
  "published": "2026-08-12",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/6fqbbpj4ystgc.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T13:21:11Z",
      "native_id": "W4414045746",
      "source": "openalex",
      "url": "https://doi.org/10.1038/s41593-026-02403-z"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2805|Neural dynamics and brain function",
      "subfield": "neuroscience"
    }
  ],
  "title": "Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations",
  "title_text": "Cross-region neuron co-firing mediated by ripple oscillations supports distributed working memory representations",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T13:20:55Z",
  "url": "https://research.draconitic.com/paper/6fqbbpj4ystgc",
  "venue": "Nature Neuroscience",
  "versions": []
}