{
  "abstract": "Background: Cognitive impairment is one of the most disabling non-motor manifestations of Parkinson’s disease (PD), substantially affecting functional independence, quality of life, and caregiver burden. Technology-assisted cognitive rehabilitation, including computerized cognitive training, virtual reality-based interventions, digital rehabilitation platforms, and remotely delivered programmes, has emerged as a potential approach to support cognitive functioning in PD. However, evidence regarding its cognitive, psychological, and implementation outcomes remains fragmented. Methods: A systematic review was conducted following PRISMA 2020, with PROSPERO identifier CRD420261433368. PubMed/MEDLINE, Scopus, Web of Science and PsycINFO were searched, with the reported final search on 30 June 2026. Structured interventions using technology as an active cognitive therapeutic component were considered. Cognitive, psychological, patient-reported, caregiver and implementation findings were synthesized narratively, distinguishing comparative effects from uncontrolled changes. Two additional reports identified during targeted revision-stage checking were assessed and included. Results: Thirteen studies were included in the current synthesis, spanning randomized, pilot, non-randomized and uncontrolled designs. Controlled cognitive findings were inconsistent. Small studies provided signals in selected executive outcomes and in time-based and verbal-response prospective memory, while the largest randomized trial found no benefit on its primary planning-accuracy endpoint. Psychological, functional and quality-of-life effects were limited or inconsistent. Implementation findings were generally favorable in selected research cohorts, with technical barriers and transient VR symptoms reported. Conclusions: Current evidence does not establish generalized, sustained comparative cognitive efficacy or consistent patient-important benefit of technology-assisted cognitive rehabilitation in PD. Selected cognitive signals warrant independent replication. Delivery feasibility, adherence and usability are distinct from clinical effectiveness and safety. Future trials should distinguish cognitive phenotypes, prespecify clinically relevant outcomes and assess everyday function alongside cognitive performance.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081 Baronissi, Italy",
    "Faculty of Psychology, University eCampus, 22060 Novedrate, Italy",
    "Centro Neurolesi Bonino Pulejo, 98124 Messina, Italy"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Colomba Pessolano",
      "orcid": "0009-0001-3152-2229"
    },
    {
      "affs": [
        0
      ],
      "name": "Marina Garofano",
      "orcid": "0000-0003-1600-4682"
    },
    {
      "affs": [
        1
      ],
      "name": "Placido Bramanti"
    },
    {
      "affs": [
        0
      ],
      "name": "Mariaconsiglia Calabrese",
      "orcid": "0000-0002-5360-7530"
    },
    {
      "affs": [
        2
      ],
      "name": "Irene Cappadona",
      "orcid": "0000-0002-3984-2331"
    },
    {
      "affs": [
        0
      ],
      "name": "Elisa Anna Contursi"
    },
    {
      "affs": [
        2
      ],
      "name": "Francesco Corallo",
      "orcid": "0000-0003-4862-3832"
    },
    {
      "affs": [
        0
      ],
      "name": "Federico Di Filippo",
      "orcid": "0000-0002-0393-9211"
    },
    {
      "affs": [
        0
      ],
      "name": "Maria Pia Di Palo",
      "orcid": "0000-0002-5443-8185"
    },
    {
      "affs": [
        0
      ],
      "name": "Andrea Marino"
    },
    {
      "affs": [
        0
      ],
      "name": "Alessia Nunziante"
    },
    {
      "affs": [
        2
      ],
      "name": "Maria Pagano",
      "orcid": "0000-0002-0978-605X"
    },
    {
      "affs": [
        0
      ],
      "name": "Marianna Amboni",
      "orcid": "0000-0002-6988-8197"
    },
    {
      "affs": [
        0
      ],
      "name": "Alessia Bramanti",
      "orcid": "0000-0002-5247-9901"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6g008pvy50f1b.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15228855",
  "fulltext_url": null,
  "id": "6g008pvy50f1b",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/22/8855",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-12",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/6g008pvy50f1b.ris",
  "sources": [
    {
      "first_seen": "2026-11-13T00:21:26Z",
      "native_id": "10.3390/jcm15228855",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/22/8855"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Technology-Assisted Cognitive Rehabilitation in Parkinson’s Disease: A Systematic Review of Cognitive, Psychological, and Implementation Outcomes",
  "title_text": "Technology-Assisted Cognitive Rehabilitation in Parkinson’s Disease: A Systematic Review of Cognitive, Psychological, and Implementation Outcomes",
  "type": "peer-reviewed",
  "updated_at": "2026-11-13T12:20:47Z",
  "url": "https://research.draconitic.com/paper/6g008pvy50f1b",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}