{
  "abstract": "Objective: Endovascular thrombectomy (EVT) achieves high rates of reperfusion, yet functional recovery remains heterogeneous. We investigated whether social-biological time misalignment modifies the association between final infarct volume and 90-day functional outcome.\n\nMethods: This retrospective cohort study included 160 patients with large vessel occlusion treated with EVT. Misalignment was quantified using a composite score incorporating occupational shift exposure and symptom onset timing. Multivariable logistic regression assessed the interaction between misalignment and final infarct volume on favorable 90-day outcome (modified Rankin Scale 0–2).\n\nResults: Misalignment was not independently associated with favorable outcome. However, a significant interaction was observed (OR = 9.70, 95% CI 1.74–54.10, LRT p = 0.008), remaining significant after FDR correction ( q = 0.034), stable across profile likelihood and Firth penalized regression. The interaction improved model fit (AIC 124.35 → 119.38) and provided modest incremental net benefit. Exploratory threshold analysis suggested a potential inflection point approximating 25 mL, but this is hypothesis-generating and requires validation.\n\nConclusion: Misalignment does not exert a uniform adverse effect but acts as a state-dependent modifier, modifying the association between final infarct volume and favorable outcome. The interaction between chronobiological state and infarct burden offers a novel framework for understanding outcome heterogeneity.",
  "abstract_shown": true,
  "affiliations": [
    "The Third Clinical Medical College, Jinzhou Medical University",
    "Department of Neurocritical Care, Liaoyang Central Hospital"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Yongbo Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Chunguang Chen"
    },
    {
      "affs": [
        1
      ],
      "name": "Chengbao Yang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6g2xg5zr1bc2v.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1985723",
  "fulltext_url": null,
  "id": "6g2xg5zr1bc2v",
  "issns": [
    "1664-2295"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1985723/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-03",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/6g2xg5zr1bc2v.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T00:26:58Z",
      "native_id": "10.3389/fneur.2026.1985723",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1985723/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "issn:1664-2295",
      "subfield": "neurology"
    }
  ],
  "title": "Social-biological misalignment modulates the prognostic impact of infarct volume after endovascular thrombectomy",
  "title_text": "Social-biological misalignment modulates the prognostic impact of infarct volume after endovascular thrombectomy",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T00:21:11Z",
  "url": "https://research.draconitic.com/paper/6g2xg5zr1bc2v",
  "venue": "Frontiers in Neurology",
  "versions": []
}