{
  "abstract": "Sargassum is a large and diversified genus of marine brown algae that is distributed widely in tropical and subtropical areas. They have been used for centuries in Asian countries, and have demonstrated a variety of health advantages, including anti-cardiovascular disease, anti-osteoarthritis, anti-cancer, anti-inflammatory, antioxidant, and hypopigmentation effects. However, the putative anti-diabetic, anti-Alzheimer's, and anti-Parkinson's diseases activities of various Sargassum spp. have not been investigated and compared thoroughly. Thus, the purpose of this study was to examine the anti-diabetic, anti-Alzheimer's, and anti-Parkinson's diseases' activities of ten Sargassum and one myagroides species collected off the Korean coast. In this study, we examined the inhibitory activity of 70% ethanolic extract of the Sargassum and myagroides species against protein tyrosine phosphatase 1B (PTP1B), α-glucosidase, peroxynitrite (ONOO⁻), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), BACE1, MAO-A, and MAO-B. Among the Sargassum and myagroides species tested, S. hemiphyllum, S. filicinum, and S. miyabei showed potent PTP1B inhibitory activity (IC₅₀ values of 2.11, 1.87, and 6.49 μg/mL, respectively), α-glucosidase inhibitory activity (IC₅₀ values of 3.67, 2.30, and 11.12 μg/mL, respectively), and ONOO⁻ scavenging activity, with IC₅₀ values of 2.07, 4.49, and 2.46 μg/mL, respectively. Moreover, S. miyabei exhibited the highest BACE1 and BChE inhibitory activity, with IC₅₀ values of 3.38 and 39.76 μg/mL, respectively. The highest MAO-A inhibitory activity was seen in S. miyabei, S. serratifolium, and S. macrocarpum, with IC₅₀ values of 16.91, 12.46, and 14.02 μg/mL, respectively. Therefore, our findings showed that Sargassum species have health benefits and may be useful in treating diabetes and neurological disorders.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Clinical Neurosciences, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.",
    "Department of Food and Life Science, Pukyong National University, Busan 48513, Republic of Korea.",
    "Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology, Seoul 05505, Republic of Korea.",
    "Department of Food Science and Human Nutrition, Jeonbuk National University, Jeonju 54896, Republic of Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Md Yousof Ali",
      "orcid": "0000-0003-1488-5711"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Se Eun Park"
    },
    {
      "affs": [
        3
      ],
      "name": "Hyun Ah Jung",
      "orcid": "0000-0001-9145-9594"
    },
    {
      "affs": [
        1
      ],
      "name": "Jae Sue Choi",
      "orcid": "0000-0001-9034-8868"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6g5pxv2bbq3cm.bib",
  "cited_by": 0,
  "doi": "10.3390/ijms27198643",
  "fulltext_url": "https://europepmc.org/articles/PMC13665272",
  "id": "6g5pxv2bbq3cm",
  "issns": [
    "1422-0067"
  ],
  "landing_url": "https://europepmc.org/article/MED/42883891",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1104|Seaweed-derived Bioactive Compounds"
    ]
  ],
  "openalex": "W7214668632",
  "pdf_url": "https://europepmc.org/articles/PMC13665272?pdf=render",
  "pmcid": "PMC13665272",
  "pmid": "42883891",
  "published": "2026-09-27",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6g5pxv2bbq3cm.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:16Z",
      "native_id": "MED:42883891",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42883891"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1104|Seaweed-derived Bioactive Compounds",
      "subfield": "ecology"
    }
  ],
  "title": "In Vitro Screening of Sargassum spp. Ethanolic Extracts for Antioxidant Activity and Inhibition of Disease-Associated Enzymatic Targets Related to Diabetes, Alzheimer's Disease, and Parkinson's Disease.",
  "title_text": "In Vitro Screening of Sargassum spp. Ethanolic Extracts for Antioxidant Activity and Inhibition of Disease-Associated Enzymatic Targets Related to Diabetes, Alzheimer's Disease, and Parkinson's Disease.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:16Z",
  "url": "https://research.draconitic.com/paper/6g5pxv2bbq3cm",
  "venue": "International journal of molecular sciences",
  "versions": []
}