{
  "abstract": "Objective\n\nTo describe the retrieval of mature oocytes after an unplanned 6-day gonadotropin-free interval during oncofertility ovarian stimulation.Design\n\nCase report.Subjects\n\nA 22-year-old active-duty soldier with a serous borderline ovarian tumor undergoing fertility preservation after ovarian surgery.Exposure\n\nProgestin-primed ovarian stimulation using follitropin alfa and medroxyprogesterone acetate as the sole luteinizing hormone suppressor. Gonadotropin administration was unexpectedly interrupted for 6 days because of a nondeferrable military summons, while oral medroxyprogesterone acetate was maintained.Main outcome measures\n\nMetaphase II (MII) oocyte yield and maturation rate.Results\n\nThe patient had undergone ovarian surgery approximately 9 months before the reference cycle and 12 months before the index cycle. Baseline antimüllerian hormone before fertility preservation was 1.77 ng/mL. In the reference cycle, 13 follicles ≥14 mm were present on the trigger day, and 13 oocytes were retrieved, including six MII oocytes that were vitrified. At the ultrasound assessment immediately preceding the gonadotropin-free interval in the index cycle, ultrasound showed nine visible follicles, including three follicles measuring <14 mm and six follicles measuring ≥14 mm. After the 6-day interval, the trigger-day ultrasound showed seven follicles ≥14 mm in diameter, ranging from 17 to 19 mm. Estradiol remained nearly stable across the interval, from 1,612 to 1,580 pg/mL, and endogenous progesterone on the trigger day was 1.1 ng/mL. Seven oocytes were retrieved, including five MII oocytes that were vitrified.Conclusion\n\nIn this selected oncofertility patient undergoing progestin-primed ovarian stimulation, an unplanned 6-day gonadotropin-free interval did not preclude retrieval of a clinically meaningful number of mature oocytes. Continuous medroxyprogesterone acetate may represent a biologically plausible protective factor against premature luteinization, although causality cannot be inferred from a single case.",
  "abstract_shown": true,
  "affiliations": [
    "Bocian Fertility Clinic, Gynecology and Obstetrics, Szczecin, Poland.",
    "Bocian Fertility Clinic, Gynecology and Obstetrics, Gdańsk, Poland.",
    "Bocian Fertility Clinic, Gynecology and Obstetrics, Białystok, Poland."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Przemysław Ciepiela"
    },
    {
      "affs": [
        1
      ],
      "name": "Arkadiusz Adamczyk"
    },
    {
      "affs": [
        1
      ],
      "name": "Joanna Aszkiełowicz"
    },
    {
      "affs": [
        1
      ],
      "name": "Weronika Józefowska"
    },
    {
      "affs": [
        2
      ],
      "name": "Grzegorz Mrugacz"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6ghkcrw1hwmdv.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xfre.2026.07.001",
  "fulltext_url": "https://europepmc.org/articles/PMC13681267",
  "id": "6ghkcrw1hwmdv",
  "issns": [
    "2666-3341"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903388",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2739|Reproductive Biology and Fertility"
    ]
  ],
  "openalex": "W7167847998",
  "pdf_url": "https://europepmc.org/articles/PMC13681267?pdf=render",
  "pmcid": "PMC13681267",
  "pmid": "42903388",
  "published": "2026-07-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6ghkcrw1hwmdv.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:59Z",
      "native_id": "MED:42903388",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903388"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2739|Reproductive Biology and Fertility",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "The progestin anchor: salvaging mature oocyte yield after an unplanned six-day gonadotropin pause in oncofertility-a case report.",
  "title_text": "The progestin anchor: salvaging mature oocyte yield after an unplanned six-day gonadotropin pause in oncofertility-a case report.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:59Z",
  "url": "https://research.draconitic.com/paper/6ghkcrw1hwmdv",
  "venue": "F&S reports",
  "versions": []
}