{
  "abstract": "BackgroundSingle-cell and spatial omics can inform research on immunotherapy response and resistance. We mapped publication activity and ClinicalTrials.gov study designs and explored evidence types in a targeted full-text subset of urologic cancer studies.MethodsWeb of Science Core Collection and Scopus records published in 2008–2025 were locked on 13 July 2026. Revision-stage eligibility reconciliation retained 538 records; 466 native Web of Science records supplied temporal-analysis inputs. A targeted full-text assessment was supplemented by a random audit of 100 previously non-selected records and independent reassessment of 40 selected studies. Evidence classes included treatment-exposed human data, association replication, computational proxies, experimental mechanisms, and prognosis. ClinicalTrials.gov records were analyzed separately.ResultsThe 538-record corpus included 440 publications from 2023–2025 (81.8%). The targeted assessment included 122 original studies among 135 assessed reports. In the random audit, 15/100 records were C1 or C2b: three C1 and 12 C2b. One C1 report contained cell-level descriptive evidence without a patient-level marker–outcome analysis. The initial evidence-class agreement was 92/100 (Cohen’s kappa, 0.890) in this audit and 31/40 (kappa, 0.682) in the selected-study reassessment. Public-cohort reuse and exploratory analyses limited clinical interpretation. Of 10 ClinicalTrials.gov records, one had a verified reported omics component, eight documented planned or ongoing components, and one was withdrawn without accrual.ConclusionBibliometric activity increased in the retained corpus. The random audit identified treatment-related reports missed by targeted retrieval, limiting claims about evidence completeness. Cell-level descriptions, patient-level associations, and locked-model validation require separate interpretation. Neither selected-study proportions nor bibliometric attention establishes field-wide clinical maturity. Registry plans require component-specific verification of implementation and reporting.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "Systematic Review",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "name": "Danhong Zhou"
    },
    {
      "name": "Junhua Li"
    },
    {
      "name": "Chenhao Tang"
    },
    {
      "name": "Yanbin Wang"
    },
    {
      "name": "Chen Song"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6gsjh6fd47zmt.bib",
  "cited_by": 0,
  "doi": "10.3389/fphar.2026.2004169",
  "fulltext_url": null,
  "id": "6gsjh6fd47zmt",
  "issns": [
    "1663-9812"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.2004169",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "feed-journal",
      "medicine/pharmacology-toxicology"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-03",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/6gsjh6fd47zmt.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:20:20Z",
      "native_id": "10.3389/fphar.2026.2004169",
      "source": "feed-frontiers",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.2004169"
    },
    {
      "first_seen": "2026-11-03T12:21:33Z",
      "native_id": "10.3389/fphar.2026.2004169",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fphar.2026.2004169/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "feed-journal:medicine/pharmacology-toxicology",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Single-cell and spatial omics in urologic cancer immunotherapy: bibliometric and registry mapping with an exploratory full-text assessment",
  "title_text": "Single-cell and spatial omics in urologic cancer immunotherapy: bibliometric and registry mapping with an exploratory full-text assessment",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T00:21:10Z",
  "url": "https://research.draconitic.com/paper/6gsjh6fd47zmt",
  "venue": "Frontiers in Pharmacology",
  "versions": []
}