{
  "abstract": "PDE4DIP/Myomegalin was originally identified as a Golgi- and centrosome-associated protein that interacts with phosphodiesterase 4D, but subsequent work has placed it within a broader network of organelle-associated signaling and cytoskeletal regulation. This review examines PDE4DIP/Myomegalin as a coiled-coil-rich scaffold linking compartmentalized cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signaling, Golgi-centrosome organization, microtubule architecture, and disease-associated pathway remodeling. At the centrosome, long PDE4D-binding myomegalin forms retain PDE4D3 and restrict local PKA activity, thereby influencing Hedgehog signaling. At the Golgi, AKAP9/AKAP450 provides a major scaffold, while selected myomegalin forms support Golgi-derived microtubule organization and endoplasmic reticulum-Golgi trafficking. In KRAS-mutant colorectal cancer models, PDE4DIP promotes tumor growth and MEK inhibitor resistance through Golgi-associated NF1/RAS pathway remodeling. In non-small cell lung cancer, PDE4DIP cooperates with AKAP9 to maintain Golgi localization and stability of PKA regulatory subunit II alpha; PDE4DIP loss activates PKA/cAMP response element-binding protein signaling and suppresses tumor growth. Cardiovascular studies link myomegalin isoform 4 to sarcomeric PKA signaling, co-occurring PDE4DIP and DES variants to conduction phenotypes, and PDE4DIP dysregulation to left ventricular noncompaction-associated cellular changes, although the evidence remains context dependent. Neurological and retinal disease associations remain largely exploratory. Recent work links a PDE4DIP-AKAP9 interaction to cytoskeletal integrity and RAS-ERK/AKT signaling in podocyte injury. Overall, PDE4DIP/Myomegalin is best understood as an organelle-associated organizer whose effects depend on the experimentally reported form, binding partners, and subcellular address rather than on a single linear pathway.",
  "abstract_shown": true,
  "affiliations": [
    "Department of General Surgery, Xuanwu Hospital, Capital Medical University, Beijing, Beijing, China.",
    "National Clinical Research Center for Geriatric Diseases, Beijing, Beijing, China."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Cong Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Chunjing Bian"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhe Wang",
      "orcid": "0000-0003-4255-6763"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Tao Luo",
      "orcid": "0000-0001-7777-0853"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6h628ffte33k5.bib",
  "cited_by": 0,
  "doi": "10.1002/cbf.70325",
  "fulltext_url": "https://europepmc.org/articles/PMC13678657",
  "id": "6h628ffte33k5",
  "issns": [
    "0263-6484",
    "1099-0844"
  ],
  "landing_url": "https://europepmc.org/article/MED/42895117",
  "language": "eng",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Phosphodiesterase function and regulation"
    ]
  ],
  "openalex": "W7222933194",
  "pdf_url": "https://europepmc.org/articles/PMC13678657?pdf=render",
  "pmcid": "PMC13678657",
  "pmid": "42895117",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6h628ffte33k5.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:37Z",
      "native_id": "MED:42895117",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42895117"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Phosphodiesterase function and regulation",
      "subfield": "molecular-biology"
    }
  ],
  "title": "PDE4DIP/Myomegalin as a Golgi-Centrosome Scaffold in Compartmentalized Signaling, Microtubule Organization, and Disease-Associated Pathway Remodeling.",
  "title_text": "PDE4DIP/Myomegalin as a Golgi-Centrosome Scaffold in Compartmentalized Signaling, Microtubule Organization, and Disease-Associated Pathway Remodeling.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:37Z",
  "url": "https://research.draconitic.com/paper/6h628ffte33k5",
  "venue": "Cell biochemistry and function",
  "versions": []
}