{ "abstract": "Objective: The Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) provides expert consensus-based pharmacotherapy recommendations tailored to Korean clinical practice and healthcare settings. This sixth revision, the KMAP-BP 2026, was developed to incorporate recent evidence and evolving expert opinion since the previous edition.\n\nMethods: A structured questionnaire was distributed to a review committee of psychiatric experts across Korea. Survey responses were analyzed and subsequently refined through expert hearings to establish consensus recommendations across the major phases of bipolar disorder.\n\nResults: For acute mania, mood stabilizer (MS) + atypical antipsychotics (AAP) combination was designated as the treatment of choice (TOC) when psychotic features were present, while MS + AAP, MS monotherapy, or AAP monotherapy were all first-line options in their absence. For depressive episodes, MS, lamotrigine (LMT), or AAP monotherapy and combinations including MS + AAP, AAP + LMT, and MS + LMT were recommended as first-line strategies for mild-to-moderate severity; notably, AAP monotherapy was elevated to first-line for severe depression, and MS + AAP was the TOC when psychotic features were present. For mixed features, MS + AAP was the TOC for manic-predominant and mixed features without predominance, while depressive-predominant mixed features allowed for a broader first-line armamentarium.\n\nConclusion: The KMAP-BP 2026 reflects both the evolving landscape of psychiatric practice in Korea and the accumulation of recent pharmacotherapy evidence, reflecting both continuity and refinement of prior recommendations. These updated recommendations are intended to serve as a practical, evidence-informed resource for clinicians navigating the complexities of bipolar disorder management.", "abstract_shown": true, "affiliations": [ "Department of Psychiatry, Jeju National University Hospital, Jeju, Korea", "Woo and Bahk Psychiatry Clinic, Seoul, Korea", "Department of Psychiatry, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea", "Department of Psychiatry, Naju National Hospital, Naju, Korea", "Department of Psychiatry, Sanggye Paik Hospital, College of Medicine, Inje University, Seoul, Korea", "Department of Psychiatry, Keyo Hospital, Uiwang, Korea", "Department of Psychiatry, Gwangmyeong Hospital, College of Medicine, Chung-Ang University, Gwangmyeong, Korea", "Department of Psychiatry, Wonkwang University Hospital, School of Medicine, Wonkwang University, Iksan, Korea", "Department of Psychiatry, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea", "Department of Psychiatry, Dong-A University Hospital, Busan, Korea", "Department of Psychiatry, Hanyang University Hospital, Seoul, Korea", "Department of Psychiatry, Korea University Guro Hospital, Seoul, Korea" ], "article_type": "research article", "arxiv": null, "author_total": 17, "authors": [ { "affs": [ 0 ], "name": "Hyun-Ju Yang", "orcid": "0000-0001-8175-6122" }, { "affs": [ 1 ], "name": "Young Sup Woo", "orcid": "0000-0002-0961-838X" }, { "affs": [ 1 ], "name": "Won-Myong Bahk", "orcid": "0000-0002-0156-2510" }, { "affs": [ 2 ], "name": "Jong-Hyun Jeong", "orcid": "0000-0003-3570-7607" }, { "affs": [ 3 ], "name": "Bo-Hyun Yoon", "orcid": "0000-0002-3882-7930" }, { "affs": [ 4 ], "name": "Won Kim", "orcid": "0000-0002-5478-7350" }, { "affs": [ 5 ], "name": "Sung-Yong Park", "orcid": "0000-0002-8685-620X" }, { "affs": [ 6 ], "name": "Jeong Seok Seo", "orcid": "0000-0002-4880-3684" }, { "affs": [ 7 ], "name": "Chan-Mo Yang", "orcid": "0000-0002-4959-7595" }, { "affs": [ 7 ], "name": "Sung-Hoon Yoon", "orcid": "0009-0000-1375-7414" }, { "affs": [ 8 ], "name": "Vin Ryu", "orcid": "0000-0003-4840-7400" }, { "affs": [ 9 ], "name": "Duk-In Jon", "orcid": "0000-0002-1565-7940" }, { "affs": [ 10 ], "name": "Nak-Young Kim", "orcid": "0000-0003-0116-6283" }, { "affs": [ 11 ], "name": "Won-Seok Choi", "orcid": "0000-0003-1774-9504" }, { "affs": [ 11 ], "name": "MoonSoo Lee", "orcid": "0000-0003-0729-6943" }, { "affs": [ 0 ], "name": "Young-Eun Jung", "orcid": "0000-0001-7608-0009" }, { "affs": [ 0 ], "name": "Moon-Doo Kim", "orcid": "0000-0002-6441-630X" } ], "bibtex": "https://research.draconitic.com/paper/6hk8089ewq62h.bib", "cited_by": 0, "doi": "10.9758/cpn.26.1490", "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13720501/", "id": "6hk8089ewq62h", "issns": [ "1738-1088", "2093-4327" ], "landing_url": "https://doi.org/10.9758/cpn.26.1490", "language": "en", "licence": "CC-BY-NC-4.0", "licence_label": "CC BY-NC 4.0", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/", "metadata_licence": null, "native_subjects": [ [ "heading", "Original Article" ], [ "openalex", "2738|Bipolar Disorder and Treatment" ] ], "openalex": "W7204527772", "pdf_url": "https://pdf.medrang.co.kr/CPN2/ahead/cpn2022.pdf", "pmcid": "PMC13720501", "pmid": "42947601", "published": "2026-08-28", "publisher": "Korean College of Neuropsychopharmacology", "ris": "https://research.draconitic.com/paper/6hk8089ewq62h.ris", "sources": [ { "first_seen": "2026-11-03T12:21:22Z", "native_id": "PMC13720501", "source": "pmc", "url": "https://doi.org/10.9758/cpn.26.1490" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2738|Bipolar Disorder and Treatment", "subfield": "psychiatry" } ], "title": "Korean Medication Algorithm Project for Bipolar Disorder 2026, Sixth Revision: An Executive Summary", "title_text": "Korean Medication Algorithm Project for Bipolar Disorder 2026, Sixth Revision: An Executive Summary", "type": "peer-reviewed", "updated_at": "2026-11-03T12:21:22Z", "url": "https://research.draconitic.com/paper/6hk8089ewq62h", "venue": "Clinical Psychopharmacology and Neuroscience", "versions": [] }