{
  "abstract": "Arterial stiffness and endothelial dysfunction are non-traditional risk markers after stroke, yet reliability and minimal detectable change (MDC) of pulse wave velocity (PWV) and flow-mediated dilation (FMD) have not been established. We examined test-retest reliability and MDC of carotid-femoral (cfPWV), carotid-radial (crPWV), and femoral-dorsalis pedis PWV (ffPWV), and absolute and relative brachial artery FMD in people >12 months post-stroke. Seventeen individuals (n=4(24%) females; 63.9{+/-}8.6 years; 4.5{+/-}2.8 years post-stroke) completed two bilateral assessments of PWV via applanation tonometry and FMD via duplex ultrasound within one week. Intraclass correlation coefficients (ICC2,1) were calculated via two-way random-effects models, and MDC derived at 68%, 90%, and 95% confidence levels. We found good-to-excellent reliability for cfPWV in paretic (ICC2,1=0.85; 95%CI:0.59,0.95) and non-paretic (ICC2,1=0.94; 95%CI:0.82,0.98) limbs, with MDC95% values of 2.23 and 1.68 m/s, respectively. crPWV and ffPWV exhibited poor reliability bilaterally (ICC2,1=0.12-0.33). Relative FMD showed-moderate reliability for paretic (ICC2,1=0.50; 95%CI:-0.20,0.85) and non-paretic (ICC=0.59; 95%CI:0.04,0.84) limbs, with MDC95% values of 6.88% and 7.65%, respectively. Reliability for absolute FMD was poor (ICC2,1=0.11-0.44). These findings support cfPWV as a reliable vascular assessments in individuals >12 months post-stroke, and provide stroke-specific MDC values to guide interpretability in future trials.",
  "abstract_shown": true,
  "affiliations": [
    "McGill University"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "J. A. Abreu"
    },
    {
      "name": "N. D'Isabella"
    },
    {
      "name": "D. Stouth"
    },
    {
      "name": "M. J. MacDonald"
    },
    {
      "name": "A. Tang"
    },
    {
      "affs": [
        0
      ],
      "name": "K. Moncion"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6j7t7j2hpjy1d.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.18.26363408",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.09.18.26363408v1.full",
  "id": "6j7t7j2hpjy1d",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.09.18.26363408v1",
  "language": null,
  "licence": "CC-BY-ND",
  "licence_label": "CC BY-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "cardiovascular medicine"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.09.18.26363408v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6j7t7j2hpjy1d.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:19Z",
      "native_id": "10.64898/2026.09.18.26363408",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.09.18.26363408v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:cardiovascular medicine",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Test re-test reliability and minimal detectable change of pulse wave velocity and flow mediated dilation in paretic and non-paretic limbs of older adults post-stroke",
  "title_text": "Test re-test reliability and minimal detectable change of pulse wave velocity and flow mediated dilation in paretic and non-paretic limbs of older adults post-stroke",
  "type": "preprint",
  "updated_at": "2026-10-30T12:19:19Z",
  "url": "https://research.draconitic.com/paper/6j7t7j2hpjy1d",
  "venue": "medRxiv",
  "versions": []
}