{
  "abstract": "Unfractionated bovine heparin (UFH-bov) is a highly sulfated and polydisperse glycosaminoglycan whose interfacial behavior can influence electrochemical mass transport. In this study, chronoamperometric current–time transients obtained for UFH-bov-containing solutions were numerically integrated to generate charge–time profiles and evaluate the concentration-dependent electrochemical response. The corresponding plots of accumulated charge as a function of the square root of time exhibited approximately linear regions within selected analysis intervals. However, UFH-bov is not directly electroactive under the experimental conditions employed and does not undergo a defined stoichiometric electron-transfer reaction. Consequently, the measured charge cannot be quantitatively related to molecular UFH-bov flux through the classical Cottrell–Anson formalism, and the experimental slopes were not converted into molecular diffusion coefficients. Instead, the slope of the selected Qt versus t1/2 region is interpreted only as an operational descriptor of the UFH-bov-dependent electrochemical response. The observed concentration dependence is consistent with interfacial phenomena, including adsorption, partial electrode blocking, and modulation of background electrochemical processes. This revised interpretation provides a conservative framework for describing square-root-of-time-dependent electrochemical behavior in the presence of a non-directly electroactive sulfated polysaccharide without assigning an unsupported molecular diffusion coefficient.",
  "abstract_shown": true,
  "affiliations": [
    "Federal University of Rio de Janeiro , , , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gabriel Ferreira Coelho",
      "orcid": "0009-0008-2406-2499"
    },
    {
      "affs": [
        0
      ],
      "name": "Leonardo Paes Cinelli"
    },
    {
      "affs": [
        0
      ],
      "name": "Nelilma Correia Romeiro",
      "orcid": "0000-0003-2562-8331"
    },
    {
      "affs": [
        0
      ],
      "name": "Rodrigo de Siqueira Melo",
      "orcid": "0000-0002-0816-462X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6jfdy1tcyt6sh.bib",
  "cited_by": 0,
  "doi": "10.1021/acsomega.6c07879",
  "fulltext_url": "https://europepmc.org/articles/PMC13688567",
  "id": "6jfdy1tcyt6sh",
  "issns": [
    "2470-1343"
  ],
  "landing_url": "https://pubs.acs.org/acsodf/article/11/41/63707/5444838/Electrochemical-Assessment-of-the-Interfacial",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1606|Electrostatics and Colloid Interactions"
    ]
  ],
  "openalex": "W7220471534",
  "pdf_url": "https://pubs.acs.org/doi/pdf/10.1021/acsomega.6c07879",
  "pmcid": "PMC13688567",
  "pmid": "42923990",
  "published": "2026-10-05",
  "publisher": "American Chemical Society (ACS)",
  "ris": "https://research.draconitic.com/paper/6jfdy1tcyt6sh.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:39Z",
      "native_id": "10.1021/acsomega.6c07879",
      "source": "crossref",
      "url": "https://pubs.acs.org/acsodf/article/11/41/63707/5444838/Electrochemical-Assessment-of-the-Interfacial"
    },
    {
      "first_seen": "2026-10-30T12:20:36Z",
      "native_id": "MED:42923990",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42923990"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1606|Electrostatics and Colloid Interactions",
      "subfield": "physical"
    }
  ],
  "title": "Electrochemical Assessment of the Interfacial Response of Unfractionated Bovine Heparin by Post-Processed Chronoamperometry",
  "title_text": "Electrochemical Assessment of the Interfacial Response of Unfractionated Bovine Heparin by Post-Processed Chronoamperometry",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:36Z",
  "url": "https://research.draconitic.com/paper/6jfdy1tcyt6sh",
  "venue": "ACS Omega",
  "versions": []
}