{
  "abstract": "Hieronymiella bedelarii is a Bolivian endemic species known from a single locality in Torotoro National Park and currently assessed as Critically Endangered on the IUCN Red List. Its alkaloid composition and cholinesterase-inhibitory activity have not previously been investigated. The GC-MS analysis identified eighteen alkaloids representing six structural types, with lycorine-, pretazettine- and homolycorine-type alkaloids being the most abundant groups. Bulbs of H. bedelarii yielded an alkaloid-enriched extract (0.80% w/w). Eight of the identified alkaloids are reported here for the first time in Hieronymiella, including candimine. Complementary UPLC-MS/MS analysis detected pretazettine and the artifact tazettine in the alkaloid-enriched extract. This extract showed stronger inhibition of acetylcholinesterase than butyrylcholinesterase, with IC₅₀ values of 10.18 and 193.19 µg·mL⁻¹, respectively. In a preliminary cultivation trial, 11 of 20 bulbils (55%) established and developed roots and leaves after 12 months under nursery conditions.",
  "abstract_shown": true,
  "affiliations": [
    "Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), CCT CONICET San Juan, Av. Libertador General San Martín 1109 (O), San Juan 5400, Argentina.",
    "Instituto de Biotecnología, Facultad de Ingeniería, Universidad Nacional de San Juan, Av. Libertador General San Martín 1109 (O), San Juan 5400, Argentina.",
    "Escuela Profesional de Ingeniería Agroindustrial, Universidad Nacional de Moquegua, Prolongación Calle Ancash s/n, Moquegua 18001, Peru.",
    "Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain."
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Olimpia Llalla-Córdova",
      "orcid": "0000-0003-4876-9540"
    },
    {
      "affs": [
        1
      ],
      "name": "Javier E Ortiz",
      "orcid": "0000-0002-6368-3115"
    },
    {
      "affs": [
        3
      ],
      "name": "Luciana R Tallini",
      "orcid": "0000-0003-3890-0971"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Victoria Parera",
      "orcid": "0000-0001-5767-5031"
    },
    {
      "affs": [
        3
      ],
      "name": "Laura Torras-Claveria",
      "orcid": "0000-0003-3598-0515"
    },
    {
      "affs": [
        1
      ],
      "name": "Lorena C Luna",
      "orcid": "0000-0001-7192-804X"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Gabriela E Feresin",
      "orcid": "0000-0002-4076-3999"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6jqmhw2bymp73.bib",
  "cited_by": 0,
  "doi": "10.3390/plants15203125",
  "fulltext_url": "https://europepmc.org/articles/PMC13709222",
  "id": "6jqmhw2bymp73",
  "issns": [
    "2223-7747"
  ],
  "landing_url": "https://europepmc.org/article/MED/42943079",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1605|Chemical synthesis and alkaloids"
    ]
  ],
  "openalex": "W7221598020",
  "pdf_url": "https://europepmc.org/articles/PMC13709222?pdf=render",
  "pmcid": "PMC13709222",
  "pmid": "42943079",
  "published": "2026-10-13",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6jqmhw2bymp73.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:12Z",
      "native_id": "MED:42943079",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42943079"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:1605|Chemical synthesis and alkaloids",
      "subfield": "organic"
    }
  ],
  "title": "The Critically Endangered Bolivian Endemic Hieronymiella bedelarii (Amaryllidaceae): First Alkaloid Profile, Cholinesterase Inhibition, and Ex Situ Conservation Insights.",
  "title_text": "The Critically Endangered Bolivian Endemic Hieronymiella bedelarii (Amaryllidaceae): First Alkaloid Profile, Cholinesterase Inhibition, and Ex Situ Conservation Insights.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:12Z",
  "url": "https://research.draconitic.com/paper/6jqmhw2bymp73",
  "venue": "Plants (Basel, Switzerland)",
  "versions": []
}