{
  "abstract": "SARS-CoV-2 infection is increasingly recognized to produce long-lasting physiological disturbances that extend beyond the acute phase. The gut microbiome has emerged as a potential contributor to post-infection outcomes, yet the longitudinal progression of microbial disruption following infection remains poorly defined. Here, we used a mouse model of SARS-CoV-2 infection to characterize gut microbiome dynamics at 7 (late acute phase), 14 (early recovery), and 21 (post-COVID condition, PCC) days post-infection (dpi). Viral RNA was detected in the lungs through 21 dpi. Longitudinal microbiome profiling revealed a two-phase restructuring marked by early shifts in Bacillota and Bacteroidota abundance, followed by pronounced post-acute dysbiosis characterized by reduced diversity, expansion of Bacillota, and near-complete loss of Bacteroidota. Functional pathway predictions showed progressive metabolic remodeling, including disruptions in nucleotide turnover, fermentation, and vitamin-related pathways. Together, these findings demonstrate that SARS-CoV-2 infection drives progressive and sustained alterations in gut microbial composition and function after the transition from acute infection through recovery into PCC.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Pulmonary Medicine, Department of Medicine, Faculty of Medicine & Dentistry, and Alberta Respiratory Centre, University of Alberta, Edmonton, Albert"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "R. Mann-Nuttel"
    },
    {
      "name": "N. S. Ogando"
    },
    {
      "name": "M. Armbruster"
    },
    {
      "name": "S. Mandal"
    },
    {
      "name": "D. Ospondpant"
    },
    {
      "name": "M. Elaish"
    },
    {
      "name": "T. C. Hobman"
    },
    {
      "name": "C. Power"
    },
    {
      "name": "P. Forsythe"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6jt14wmeh90tk.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.16.751817",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.16.751817v1.full",
  "id": "6jt14wmeh90tk",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.16.751817v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "microbiology"
    ],
    [
      "openalex",
      "1312|Gut microbiota and health"
    ]
  ],
  "openalex": "W7213674050",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.16.751817v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-16",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6jt14wmeh90tk.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:23:11Z",
      "native_id": "10.64898/2026.09.16.751817",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.16.751817v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:microbiology",
      "subfield": "microbiology"
    }
  ],
  "title": "Progressive Post-Acute Gut Microbiome Disruption Following SARS-CoV-2 Infection in Mice",
  "title_text": "Progressive Post-Acute Gut Microbiome Disruption Following SARS-CoV-2 Infection in Mice",
  "type": "preprint",
  "updated_at": "2026-10-30T12:23:11Z",
  "url": "https://research.draconitic.com/paper/6jt14wmeh90tk",
  "venue": "bioRxiv",
  "versions": []
}