{
  "abstract": "目的探讨血清高尔基蛋白73（Golgi protein 73，GP73）与肝纤维化风险的关系，并评价其在健康体检人群肝纤维化筛查中的应用价值。方法纳入2022—2024年于吉林大学中日联谊医院体检中心接受健康体检的1 676例受检者。采用纤维化-4指数进行肝纤维化风险分层，并采用化学发光免疫分析法检测血清GP73水平。采用Logistic回归分析GP73与肝纤维化风险的关联，采用受试者工作特征（ROC）曲线评价不同模型对肝纤维化高风险个体的判别效能，并应用限制性立方样条（RCS）分析GP73与肝纤维化风险之间的剂量-反应关系。结果肝纤维化高风险组占总受检者23.2%。肝纤维化高风险组GP73水平高于低风险组［41.95 vs.36.36 ng/mL，P<0.001］。多因素Logistic回归分析显示，GP73水平升高与肝纤维化风险增加独立相关（OR=1.014，95%CI：1.009～1.020）。GP73单独模型、临床指标模型及联合模型的AUC分别为0.585、0.668和0.674；DeLong检验显示，联合模型与临床指标模型的AUC差异无统计学意义（P=0.417）。GP73单独筛查的最大约登指数为0.220，对应最佳截断值为37.52 ng/mL。RCS分析显示GP73与肝纤维化风险总体关联具有统计学意义（P overall<0.001），未发现显著非线性关联（P non-linear=0.9 187）。结论血清GP73水平升高与肝纤维化高风险独立相关，两者主要呈近似线性剂量-反应关系。GP73可为健康体检人群肝纤维化风险评估提供一定的辅助信息，但其单独判别能力及在传统临床指标基础上的附加判别价值有限。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "王璞"
    },
    {
      "name": "邱仁娜"
    },
    {
      "name": "梁卓帅"
    },
    {
      "name": "韩宇家"
    },
    {
      "name": "兴芝博"
    },
    {
      "name": "赵晴"
    },
    {
      "name": "何文君"
    },
    {
      "name": "王长宏"
    },
    {
      "name": "孙晶"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6k1zxegh7wxpw.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.008",
  "id": "6k1zxegh7wxpw",
  "issns": [
    "1007-4287"
  ],
  "landing_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.008",
  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RB1-214"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": "Editorial Office of Chinese Journal of Laboratory Diagnosis",
  "ris": "https://research.draconitic.com/paper/6k1zxegh7wxpw.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:42Z",
      "native_id": "25b6c4bbba954709aa2c1387159d07ba",
      "source": "doaj",
      "url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.008"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RB1-214",
      "subfield": "general"
    }
  ],
  "title": "血清GP73在健康体检人群肝纤维化风险中的相关性研究",
  "title_text": "血清GP73在健康体检人群肝纤维化风险中的相关性研究",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:42Z",
  "url": "https://research.draconitic.com/paper/6k1zxegh7wxpw",
  "venue": "Zhongguo shiyan zhenduanxue",
  "versions": []
}