{
  "abstract": "Purpose: To assess whether specific markers of oxidative stress and DNA damage are expressed at higher levels in primordial follicles of patients with endometriomas compared to age-matched controls.\n\nMethods: A retrospective pilot cohort study was conducted using ovarian tissue from patients who underwent unilateral or bilateral salpingo-oophorectomy for symptomatic endometriomas, with controls undergoing an identical procedure for other benign gynecologic conditions. Immunohistochemistry (IHC) was used to assess percent positivity in primordial follicles for 4-hydroxy-2-nonenal (4-HNE) as a marker of oxidative stress; 8-Oxoguanine (8-Oxo) and phosphorylated H2AX (γH2AX) for DNA damage. Chi-square tests were used for categorical variables and Student t-tests for continuous variables, with p < 0.05 considered significant.\n\nResults: Twenty-nine patients were included (8 controls, 21 with endometriomas). Age (39.4 ± 5.1 vs. 37.1 ± 4.6 years, p = 0.269), BMI (33.6 ± 10.6 vs. 29.5 ± 7.8 kg/m2, p = 0.310) were similar between groups. Racial distribution, nulliparity, hormonal therapy use, and smoking status were also comparable. The average endometrioma size was 6.6 ± 2.8 cm. All molecular markers showed higher percent positivity in the endometrioma group compared to the control group. γH2AX demonstrated a statistically significant increase (63.6% vs. 50.1%, p = 0.033). 8-Oxo (67.5% vs. 55.8%, p = 0.070) and 4-HNE (65.1% vs. 61.8%, p = 0.168) were also elevated in the endometrioma group but did not reach statistical significance.\n\nConclusion: Patients with endometriomas demonstrated increased follicular DNA damage, with elevated γH2AX expression, supporting the notion that endometriomas may impair follicular quality through DNA damage mechanisms.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s10815-026-03990-3.",
  "abstract_shown": true,
  "affiliations": [
    "Women and Infants Hospital of Rhode Island, Providence, United States",
    "Warren Alpert Medical School of Brown University, Providence, United States"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Luce A. Kassi"
    },
    {
      "affs": [
        1
      ],
      "name": "Sanjana Konda"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Joyce Ou"
    },
    {
      "affs": [
        0
      ],
      "name": "Julia McAdams"
    },
    {
      "affs": [
        0
      ],
      "name": "Robin Cram"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "May-Tal Sauerbrun-Cutler"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Kathryn Grive"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6keaaz7pex6t8.bib",
  "cited_by": 0,
  "doi": "10.1007/s10815-026-03990-3",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13731570/",
  "id": "6keaaz7pex6t8",
  "issns": [
    "1058-0468",
    "1573-7330"
  ],
  "landing_url": "https://doi.org/10.1007/s10815-026-03990-3",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2743|Endometriosis Research and Treatment"
    ]
  ],
  "openalex": "W4416973621",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s10815-026-03990-3.pdf",
  "pmcid": "PMC13731570",
  "pmid": "42581193",
  "published": "2026-08-11",
  "publisher": "Springer",
  "ris": "https://research.draconitic.com/paper/6keaaz7pex6t8.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:21:44Z",
      "native_id": "PMC13731570",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s10815-026-03990-3"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2743|Endometriosis Research and Treatment",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Endometriosis and ovarian aging: a pilot study exploring oxidative stress and DNA damage markers",
  "title_text": "Endometriosis and ovarian aging: a pilot study exploring oxidative stress and DNA damage markers",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:21:44Z",
  "url": "https://research.draconitic.com/paper/6keaaz7pex6t8",
  "venue": "Journal of Assisted Reproduction and Genetics",
  "versions": []
}