{
  "abstract": "Oxidative stress, bacterial infection, and persistent inflammatory responses are key inhibitory factors for chronic wound healing, yet most conventional dressings fail to simultaneously address these pathological barriers. This study presents a multifunctional composite film incorporating manganese-curcumin (Mn-Cur) nanozymes prepared via a facile, carrier-free synthesis. These nanozymes exhibit dual superoxide dismutase (SOD)- and catalase (CAT)-mimetic activities, enabling efficient elimination of superoxide anion radicals (•O₂ ⁻) and hydrogen peroxide (H₂O₂). A rapid Prussian blue (PB) coating is introduced onto the Mn-Cur surface to enhance biocompatibility and confer photothermal antibacterial capability, forming Mn-Cur@PB (MC@PB) nanocomposites. The engineered nanozymes efficiently scavenge excess reactive oxygen species (ROS), exert potent antibacterial activity, and attenuate pro-inflammatory macrophage activation while inducing an immunoregulatory phenotype. The MC@PB nanocomposites are subsequently incorporated into a silk fibroin (SF)/polyvinyl butyral (PVB) matrix and cast into an in situ-forming wound dressing (denoted SPMP), bridging nanomaterial design and practical wound management. In vivo evaluation using infected diabetic wound models confirms that, under near-infrared (NIR) irradiation, the SPMP dressing effectively eliminates bacteria, alleviates inflammation, facilitates collagen deposition and angiogenesis, and accelerates wound closure. This multifunctional SPMP film represents a promising candidate for clinical chronic wound treatment.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Advanced Technology for Material Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, China",
    "Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yuxin Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Long Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Weifeng Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Bingjie Sun"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyao Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaohong Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Meiyu Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinyu Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing Tu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6kjf2rpbzryp9.bib",
  "cited_by": 0,
  "doi": "10.1016/j.mtbio.2026.103759",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717171/?tool=EBI",
  "id": "6kjf2rpbzryp9",
  "issns": [
    "2590-0064"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13717171",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Full Length Article"
    ],
    [
      "openalex",
      "2742|Wound Healing and Treatments"
    ]
  ],
  "openalex": "W7222949753",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717171/pdf/?tool=EBI",
  "pmcid": "PMC13717171",
  "pmid": "42959546",
  "published": "2026-10-19",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/6kjf2rpbzryp9.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:38Z",
      "native_id": "PMC:PMC13717171",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13717171"
    },
    {
      "first_seen": "2026-11-01T00:20:50Z",
      "native_id": "MED:42959546",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959546"
    },
    {
      "first_seen": "2026-11-02T12:21:32Z",
      "native_id": "PMC13717171",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.mtbio.2026.103759"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2742|Wound Healing and Treatments",
      "subfield": "general"
    }
  ],
  "title": "In situ-forming manganese-curcumin nanozyme film promotes diabetic wound healing via photothermal antibacterial and anti-inflammatory actions",
  "title_text": "In situ-forming manganese-curcumin nanozyme film promotes diabetic wound healing via photothermal antibacterial and anti-inflammatory actions",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:32Z",
  "url": "https://research.draconitic.com/paper/6kjf2rpbzryp9",
  "venue": "Materials today. Bio",
  "versions": []
}