{
  "abstract": "Background & Aims: Patient-reported outcomes (PRO) are essential for monitoring disease activity and treatment response in inflammatory bowel disease (IBD). The conventional PRO-2 requires several days of prospective symptom recording, increasing participant burden and attrition in longitudinal research. We evaluated whether a “rapid PRO-2”, using 2 days of data collected retrospectively and prospectively in a single day, could serve as a reliable and pragmatic alternative to a 4-day PRO-2.\n\nMethods: Using data from the ongoing IBD-RESPONSE cohort (n = 684 Crohn’s disease [CD]; n = 548 ulcerative colitis [UC]), we compared 4-day PRO-2 and rapid PRO-2 scores at baseline and 14 weeks post-therapy to assess disease activity, clinical (non) response and remission.\n\nResults: At baseline, 87.1% (596/684) of CD and 88.7% (486/548) of UC patients remained in the same active/inactive disease activity category (Cohen’s kappa: CD 0.715; UC 0.762; both P < .001). At week 14, 77% (CD; 195/252) and 83.1% (UC; 193/232) remained in the same non-response/response/remission category (Cohen’s kappa: CD 0.653; UC 0.743; both P < .001). Discrepancies mainly involved adjacent category shifts (ie, between response and remission, or non-response and response), with minimal re-classification between remission and non-response (n = 7 CD and n = 2 UC). Greater symptom variability across the 4 days increased the likelihood of switching between remission and non-response (odds ratio [95% confidence interval], CD 5.0 [3.65–6.85]; UC 7.8 [5.6–11.0], both P < .001). Responsiveness to clinical change was comparable between instruments.\n\nConclusions: The rapid PRO-2 retains essential symptom data and demonstrates strong agreement with the 4-day PRO-2, offering an alternative in longitudinal studies to minimize burden and attrition.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 100,
  "authors": [
    {
      "name": "Lauren C Beck",
      "orcid": "0000-0002-8470-9679"
    },
    {
      "name": "Gregory R Young",
      "orcid": "0000-0001-5342-1421"
    },
    {
      "name": "Nicola J Wyatt",
      "orcid": "0000-0001-5050-327X"
    },
    {
      "name": "Robert J Mulligan",
      "orcid": "0009-0009-6751-1095"
    },
    {
      "name": "Robert D Lees",
      "orcid": "0009-0003-7439-1681"
    },
    {
      "name": "Chaonan Dong",
      "orcid": "0000-0001-5337-5779"
    },
    {
      "name": "Hannah Watson",
      "orcid": "0000-0002-7965-938X"
    },
    {
      "name": "Trevor Liddle"
    },
    {
      "name": "Ally Speight",
      "orcid": "0000-0003-3184-9181"
    },
    {
      "name": "Dean M Allerton",
      "orcid": "0000-0003-0507-4343"
    },
    {
      "name": "Victoria Hildreth"
    },
    {
      "name": "Naomi S McGregor",
      "orcid": "0000-0002-5961-124X"
    },
    {
      "name": "Ruth Wood",
      "orcid": "0000-0002-8296-1774"
    },
    {
      "name": "Mary Doona"
    },
    {
      "name": "Debbie Alexander"
    },
    {
      "name": "Samantha Baillie"
    },
    {
      "name": "Biljana Brezina",
      "orcid": "0000-0001-5060-5604"
    },
    {
      "name": "Beatriz Camesella Perez"
    },
    {
      "name": "Bessie Cipriano",
      "orcid": "0000-0003-1798-2007"
    },
    {
      "name": "Jessica Cordle"
    },
    {
      "name": "Dominic Devine",
      "orcid": "0009-0008-9703-1925"
    },
    {
      "name": "Alexander T Elford",
      "orcid": "0000-0001-6144-1369"
    },
    {
      "name": "Kay Goulden",
      "orcid": "0009-0006-0306-4220"
    },
    {
      "name": "Marie Green",
      "orcid": "0000-0003-1726-7054"
    },
    {
      "name": "Hannah Husband",
      "orcid": "0000-0003-1024-9988"
    },
    {
      "name": "Lorna Ingoe"
    },
    {
      "name": "Lauren John",
      "orcid": "0009-0000-4167-9820"
    },
    {
      "name": "Sunita Dias Juliao"
    },
    {
      "name": "Andrew King"
    },
    {
      "name": "Klaartje Kok",
      "orcid": "0000-0002-5942-9149"
    },
    {
      "name": "Yasmin Laidler"
    },
    {
      "name": "Isabel Laszczak"
    },
    {
      "name": "Sarah Lawrence"
    },
    {
      "name": "Irish Lee"
    },
    {
      "name": "Melanie Love"
    },
    {
      "name": "Julian Marchesi"
    },
    {
      "name": "Claire McQuillian"
    },
    {
      "name": "Helen Millage"
    },
    {
      "name": "Ibinye Minimah"
    },
    {
      "name": "Alison Moss"
    },
    {
      "name": "Felicia Onoviran",
      "orcid": "0000-0002-2812-0827"
    },
    {
      "name": "Christopher Palmer-Jones",
      "orcid": "0009-0003-0607-7877"
    },
    {
      "name": "Gareth C Parkes",
      "orcid": "0000-0002-5285-7714"
    },
    {
      "name": "Sally Payton",
      "orcid": "0009-0008-1523-1633"
    },
    {
      "name": "Jahleesha Pinney"
    },
    {
      "name": "Kiran Prabhu"
    },
    {
      "name": "Chandni Radia",
      "orcid": "0009-0002-1572-2172"
    },
    {
      "name": "Parizade Raymode",
      "orcid": "0009-0009-5901-6094"
    },
    {
      "name": "Juan de la Revilla Negro",
      "orcid": "0009-0002-1036-6834"
    },
    {
      "name": "Francesca Rosa",
      "orcid": "0000-0002-1502-1344"
    },
    {
      "name": "Lydia Scarlett"
    },
    {
      "name": "Mohammed T Sharip"
    },
    {
      "name": "Natalie Shields",
      "orcid": "0009-0006-9353-5996"
    },
    {
      "name": "Sreedhar Subramanian",
      "orcid": "0000-0002-6483-1730"
    },
    {
      "name": "Robert Varley",
      "orcid": "0009-0004-0980-7596"
    },
    {
      "name": "Busiswa Vuyelele-Titchmarsh"
    },
    {
      "name": "Valentina Toska"
    },
    {
      "name": "Kevin Whelan",
      "orcid": "0000-0001-5414-2950"
    },
    {
      "name": "Kate Wistance"
    },
    {
      "name": "Mark Yongco",
      "orcid": "0009-0007-3127-7490"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6kjr5xbdyk0n7.bib",
  "cited_by": 0,
  "doi": "10.1093/ecco-jcc/jjag153",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13730273/?tool=EBI",
  "id": "6kjr5xbdyk0n7",
  "issns": [
    "1873-9946",
    "1876-4479"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13730273",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "AcademicSubjects/MED00260"
    ],
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2715|Inflammatory Bowel Disease"
    ]
  ],
  "openalex": "W7223218949",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13730273/pdf/?tool=EBI",
  "pmcid": "PMC13730273",
  "pmid": "42976274",
  "published": "2026-10-01",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/6kjr5xbdyk0n7.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T15:20:47Z",
      "native_id": "PMC:PMC13730273",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13730273"
    },
    {
      "first_seen": "2026-11-07T12:22:52Z",
      "native_id": "PMC13730273",
      "source": "pmc",
      "url": "https://doi.org/10.1093/ecco-jcc/jjag153"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2715|Inflammatory Bowel Disease",
      "subfield": "general"
    }
  ],
  "title": "Longitudinal timepoint assessment of patient-reported clinical disease activity in ulcerative colitis and Crohn’s disease: suitability of a rapid Patient-Reported Outcome 2 (PRO-2) assessment",
  "title_text": "Longitudinal timepoint assessment of patient-reported clinical disease activity in ulcerative colitis and Crohn’s disease: suitability of a rapid Patient-Reported Outcome 2 (PRO-2) assessment",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:52Z",
  "url": "https://research.draconitic.com/paper/6kjr5xbdyk0n7",
  "venue": "Journal of Crohn's & colitis",
  "versions": []
}