{
  "abstract": "Background: Long-term survival in sarcoidosis patients can be predicted by several clinical and laboratory parameters. Hypercalcemia serves as a predominant, negative prognostic factor. In the current study, we aimed to identify other patient characteristics influencing outcomes over a 10-year period. Methods: This was a retrospective analysis of hospitalized sarcoidosis patients in a large, tertiary medical center. Results: During a 10-year period between 2014 and 2024, data from 89 sarcoidosis patients was collected using MDClone data-mining software. Overall, 13 patients suffered from hypercalcemia (median, corrected for blood albumin: 10.3 mg/dL [9.9–10.5] vs. 9.5 [9.2–9.8], p < 0.001). Patients with hypercalcemia had higher rates of renal failure (30.8% vs. 3.9%, p = 0.008), lower platelet counts (median 153 K/mcl [113–170] vs. 230 [190.7–263.5], p < 0.001), lower hemoglobin concentrations (median 10.2 g/dL [10.0–11.3] vs. 12.5 [10.8–13.6], p < 0.01), higher urea blood levels (median 88 mg/dL [46–130] vs. 38.5 [30–47.2], p < 0.001), higher creatinine levels (median 1.48 mg/dL [1.31–1.6] vs. 0.9 [0.76–1.05], p < 0.001), and lower albumin (mean 3.07 g/dL ± 0.47 vs. 3.57 ± 0.56, p = 0.003). Hypercalcemia was associated with lower, post-discharge survival rates (median 4.8 years [2.6–7.3] vs. 7.9 [3.3–12.1], p = 0.045) and higher rates of 3-year, post-discharge mortality (30.8% vs. 7.9%, p = 0.036). Thrombocytopenia was present in six patients (6.7%); four (66.7%) died within three years, compared with six of 83 patients without thrombocytopenia (7.2%; p = 0.001). In univariate analysis, hypercalcemia and thrombocytopenia were both associated with a higher risk of mortality within 3 years (HR = 4.11, 95% CI 1.16–14.57, p = 0.029 and HR = 13.92, 95% CI 3.88–49.93, p < 0.001, respectively). However, in a multivariate analysis, only patient age and thrombocytopenia continued to be associated with a statistically significant higher risk of death (HR = 7.04, 95% CI 1.46–33.99, p = 0.015). Five of the six patients with thrombocytopenia (83.3%) were subsequently diagnosed with hematologic malignancy, months to years after thrombocytopenia was identified. Conclusions: Thrombocytopenia was associated with higher three-year mortality and may represent a clinical warning sign for occult or subsequently diagnosed hematologic malignancy in patients with sarcoidosis.",
  "abstract_shown": true,
  "affiliations": [
    "Education Authority, Chaim Sheba Medical Center, Ramat Gan 5262000, Israel",
    "Faculty of Healthcare and Medicine, Ariel University, Ariel 40700, Israel",
    "Faculty of Medicine, Nicosia University, P.O. Box 24005, Nicosia CY-1700, Cyprus",
    "Gray Faculty of Heath Science and Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel",
    "Medicine Division, Ort Melton School of Science. Bat-Yam 5964712, Israel",
    "Department of Pediatric Intensive Care, Safra Children’s Hospital, Chaim Sheba Medical Center, Tel-Hashomer 5265601, Israel"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Guy Dumanis"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Tamir Ofek",
      "orcid": "0009-0009-5302-1984"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Adi Gubbay",
      "orcid": "0009-0007-8468-2254"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Coral Tal"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Ilana Moshkovich"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Noam Klegar",
      "orcid": "0009-0008-5982-8378"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Paz Agam Ohayon"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Noa Tennenhaus",
      "orcid": "0009-0005-6294-5055"
    },
    {
      "affs": [
        0,
        3
      ],
      "name": "Gad Segal",
      "orcid": "0000-0002-3851-3245"
    },
    {
      "affs": [
        4
      ],
      "name": "Yigal Farkash"
    },
    {
      "affs": [
        4
      ],
      "name": "Daniel Bendersky"
    },
    {
      "affs": [
        4
      ],
      "name": "Moria Tzibin"
    },
    {
      "affs": [
        3,
        5
      ],
      "name": "Reut Kassif Lerner",
      "orcid": "0000-0003-1018-1071"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6kxsw6ft4b87h.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15208170",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706558/?tool=EBI",
  "id": "6kxsw6ft4b87h",
  "issns": [
    "2077-0383"
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  "landing_url": "https://www.mdpi.com/2077-0383/15/20/8170",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2737|Sarcoidosis and Beryllium Toxicity Research"
    ]
  ],
  "openalex": "W7223096799",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13706558/pdf/?tool=EBI",
  "pmcid": "PMC13706558",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/6kxsw6ft4b87h.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:01Z",
      "native_id": "10.3390/jcm15208170",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/20/8170"
    },
    {
      "first_seen": "2026-10-30T12:21:31Z",
      "native_id": "PMC:PMC13706558",
      "source": "europepmc",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Sarcoidosis and Beryllium Toxicity Research",
      "subfield": "physiology"
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  ],
  "title": "Thrombocytopenia Warrants Clinical Attention in Hospitalized Patients with Sarcoidosis",
  "title_text": "Thrombocytopenia Warrants Clinical Attention in Hospitalized Patients with Sarcoidosis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:31Z",
  "url": "https://research.draconitic.com/paper/6kxsw6ft4b87h",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}