{
  "abstract": "Dyshomeostasis of the autonomic nervous system (ANS) drives chronic illnesses including hypertension, heart failure, diabetes mellitus, metabolic syndrome, Parkinson’s disease, and traumatic brain injury. Abnormal neuronal excitability within central nervous system (CNS) nuclei is a major cause of ANS dysfunction. Small-conductance calcium-activated potassium (SK) channels govern excitability in central autonomic nuclei, sustaining neuronal excitation-inhibition balance via medium afterhyperpolarization potentials (mAHP)-mediated negative feedback. This review describes SK channels’ molecular structure and electrophysiology, maps central sympathetic-parasympathetic neuroanatomical pathways, and highlights pathological impacts of the dysfunction of SK channels among the hypothalamic paraventricular nucleus (PVN) and nucleus ambiguus (NA). It also summarizes SK channels-centered regulatory approaches: epigenetics (DNA methylation, miRNA modulation), post-translational modification (phosphorylation, ubiquitination), protein interaction, metabolites, and synthetic exogenous agonists and antagonists. These results offer a theoretical basis and candidate targets to decode the neurogenic hypertension and diabetes mechanisms and facilitate bench-to-clinic translation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biotechnology, School of Life Science, Jilin Normal University, Siping 136000, China",
    "Department of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI 49931-1200, USA",
    "Department of Neuroscience, Evelyn F. and William L. McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA",
    "School of Life Sciences, Shanghai University, Shanghai 200444, China",
    "Biomolecular Science Center, College of Medicine, Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Renjun Wang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhengwei Li"
    },
    {
      "affs": [
        1
      ],
      "name": "Andrew D. Chapp"
    },
    {
      "affs": [
        2
      ],
      "name": "Min Lin"
    },
    {
      "affs": [
        3
      ],
      "name": "Dong-Shu Du"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhiying Shan"
    },
    {
      "affs": [
        4
      ],
      "name": "Zixi Jack Cheng"
    },
    {
      "affs": [
        1
      ],
      "name": "Qing-Hui Chen"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6m6086mtb89d3.bib",
  "cited_by": 0,
  "doi": "10.1007/s12264-026-01715-1",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13700009/",
  "id": "6m6086mtb89d3",
  "issns": [
    "1673-7067",
    "1995-8218"
  ],
  "landing_url": "https://doi.org/10.1007/s12264-026-01715-1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "1312|Ion channel regulation and function"
    ]
  ],
  "openalex": "W7213554747",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s12264-026-01715-1.pdf",
  "pmcid": "PMC13700009",
  "pmid": "42758261",
  "published": "2026-09-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6m6086mtb89d3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:31Z",
      "native_id": "PMC13700009",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s12264-026-01715-1"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Ion channel regulation and function",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Small-Conductance Ca2+-Activated K+ Channels and Their Regulation of Excitability of Autonomic Neurons",
  "title_text": "Small-Conductance Ca2+-Activated K+ Channels and Their Regulation of Excitability of Autonomic Neurons",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:36:29Z",
  "url": "https://research.draconitic.com/paper/6m6086mtb89d3",
  "venue": "Neuroscience bulletin",
  "versions": []
}