{
  "abstract": "Highly pathogenic avian influenza (HPAI) clade 2.3.4.4b H5N1 circulated widely in lactating dairy cows in the United States following the initial detection in 2024. Due to the critical need for intervention strategies for this outbreak, we evaluated antibody and cellular immune responses of a clade 2.3.4.4b H5 mRNA-LNP vaccine in calves. We found that the H5 mRNA-LNP vaccine induced a robust antibody and CD8 + T cell-mediated immune response and conferred protection against clade 2.3.4.4b H5N1 infection. IMPORTANCE It is important to develop vaccines that limit clade 2.3.4.4b H5N1 infection in cattle. In this study, we found that a new H5 mRNA-lipid nanoparticle vaccine is immunogenic when delivered intramuscularly to male Holstein calves.",
  "abstract_shown": true,
  "affiliations": [
    "National Animal Disease Center – United States Department of Agriculture, Agricultural Research Service, Ames, IA, USA",
    "Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA",
    "Infection Disease Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA",
    "Penn Institute of RNA Innovation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Carine K. Souza",
      "orcid": "0000-0002-3082-0398"
    },
    {
      "affs": [
        1
      ],
      "name": "Jefferson José da Silva Santos",
      "orcid": "0000-0001-5895-4163"
    },
    {
      "affs": [
        0
      ],
      "name": "Paola Mercedes Boggiatto",
      "orcid": "0000-0002-3426-2426"
    },
    {
      "affs": [
        0
      ],
      "name": "Haley M. Sterle"
    },
    {
      "affs": [
        0
      ],
      "name": "Bailey L. Arruda",
      "orcid": "0000-0001-7407-9952"
    },
    {
      "affs": [
        0
      ],
      "name": "Mitchell V. Palmer",
      "orcid": "0000-0002-5902-3333"
    },
    {
      "affs": [
        0
      ],
      "name": "Alessandra Campos"
    },
    {
      "affs": [
        1
      ],
      "name": "Jiaojiao Liu",
      "orcid": "0000-0002-3665-4626"
    },
    {
      "affs": [
        1
      ],
      "name": "Naiqing Ye",
      "orcid": "0009-0003-6232-8570"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Drew Weissman"
    },
    {
      "affs": [
        1
      ],
      "name": "Scott E. Hensley",
      "orcid": "0000-0002-2928-7506"
    },
    {
      "affs": [
        0
      ],
      "name": "Amy L. Vincent Baker",
      "orcid": "0000-0002-4953-7285"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6mw5p767asqdp.bib",
  "cited_by": 10,
  "doi": "10.1128/jvi.01289-26",
  "fulltext_url": null,
  "id": "6mw5p767asqdp",
  "issns": [
    "0022-538X",
    "1070-6321",
    "1098-5514"
  ],
  "landing_url": "https://doi.org/10.1128/jvi.01289-26",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2713|Influenza Virus Research Studies"
    ]
  ],
  "openalex": "W7221050782",
  "pdf_url": null,
  "pmcid": null,
  "pmid": "42847707",
  "published": "2026-10-08",
  "publisher": "American Society for Microbiology",
  "ris": "https://research.draconitic.com/paper/6mw5p767asqdp.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:56Z",
      "native_id": "W7221050782",
      "source": "openalex",
      "url": "https://doi.org/10.1128/jvi.01289-26"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2713|Influenza Virus Research Studies",
      "subfield": "epidemiology-public-health"
    }
  ],
  "title": "H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves",
  "title_text": "H5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T13:20:37Z",
  "url": "https://research.draconitic.com/paper/6mw5p767asqdp",
  "venue": "Journal of Virology",
  "versions": []
}