{
  "abstract": "Therapeutic IgG anti-IgE antibodies are benchmarked by their ability to interfere with IgE-Fc[epsilon]RI binding, but their activity within IgE and IgG-containing immune complexes remains poorly defined. Here we show that omalizumab and ligelizumab form binary IgE-IgG and ternary allergen-containing immune complexes with distinct functional properties. In primary human leukocytes, these complexes exhibited antibody- and composition-dependent patterns of cellular association and activation. Using multiplexed focal molography, we resolved Fc receptor engagement across free and complexed antibody states and identified distinct receptor-binding signatures for omalizumab- and ligelizumab-containing complexes. Notably, allergen incorporation reversed the relative ability of the two antibodies to neutralize IgE-Fc[epsilon]RI interactions and remodelled Fc[gamma]R binding. Thus, immune-complex composition is a determinant of therapeutic antibody function.",
  "abstract_shown": true,
  "affiliations": [
    "Inselspital Bern, University of Bern"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "M. Miro Navarro"
    },
    {
      "name": "A. G. Geiger"
    },
    {
      "name": "S. Notova"
    },
    {
      "name": "A. Frutiger"
    },
    {
      "name": "M. F. Bachmann"
    },
    {
      "affs": [
        0
      ],
      "name": "P. Engeroff"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6mxdfcn9xmzk7.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.11.06.764804",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.11.06.764804v1.full",
  "id": "6mxdfcn9xmzk7",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.11.06.764804v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "immunology"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.11.06.764804v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6mxdfcn9xmzk7.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:46Z",
      "native_id": "10.64898/2026.11.06.764804",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.11.06.764804v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:immunology",
      "subfield": "immunology"
    }
  ],
  "title": "Therapeutic anti-IgE antibodies generate distinct functional immune complex signatures",
  "title_text": "Therapeutic anti-IgE antibodies generate distinct functional immune complex signatures",
  "type": "preprint",
  "updated_at": "2026-11-09T12:21:46Z",
  "url": "https://research.draconitic.com/paper/6mxdfcn9xmzk7",
  "venue": "bioRxiv",
  "versions": []
}