{
  "abstract": "BackgroundSickle cell anaemia (SCA) is characterised by chronic haemolysis, inflammation, platelet activation, and recurrent vaso-occlusive complications. Mean platelet volume (MPV) is a readily available platelet index, but evidence regarding its relationship with disease severity in paediatric SCA remains limited and inconsistent, particularly in African populations.\n\nObjectiveTo evaluate the relationship between MPV and disease severity among children with SCA in Kwara State, North-Central Nigeria.\n\nMethodsThis hospital-based cross-sectional study included 51 clinically stable children with confirmed SCA consecutively recruited from the paediatric haematology clinic of Children Emergency Specialist Hospital, Ilorin. Complete blood count, including MPV, was performed using a Rayto RT-7600 automated haematology analyser. Disease severity was assessed using a composite clinical and laboratory scoring system based on a previously described method. Pearsons correlation, Spearmans rank correlation, simple linear regression, and the Kruskal-Wallis test were used as appropriate. Statistical significance was set at p < 0.05.\n\nResultsOf 51 participants, 14 (27.5%) had mild, 33 (64.7%) moderate, and 4 (7.8%) severe disease. Mean MPV was 9.34 {+/-} 0.76 fL (range, 8.0-11.2). Pearsons correlation showed a weak positive, non-significant linear relationship with severity score (r = 0.231, p = 0.103), whereas Spearmans analysis showed a weak positive monotonic association ({rho} = 0.286, p = 0.042). Regression explained 5.3% of severity-score variation (R{superscript 2} = 0.053, p = 0.103). MPV did not differ significantly across severity categories (H = 2.163, p = 0.339). MPV correlated inversely with haemoglobin (r = -0.556, p < 0.001) and positively with platelet count (r = 0.307, p = 0.029).\n\nConclusionMPV showed a weak relationship with disease severity but inconsistent statistical evidence across analyses. The limited explained variance and absence of significant differences between severity categories do not support MPV as a standalone severity marker. Larger longitudinal studies are warranted.",
  "abstract_shown": true,
  "affiliations": [
    "University of Lagos"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "F. D. Oladimeji"
    },
    {
      "affs": [
        0
      ],
      "name": "A. D. Adewoyin"
    },
    {
      "name": "K. O. Oyeleke"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6n6rcmn6d5aj7.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.08.28.26361349",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.08.28.26361349v1.full",
  "id": "6n6rcmn6d5aj7",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.08.28.26361349v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "hematology"
    ],
    [
      "openalex",
      "2716|Hemoglobinopathies and Related Disorders"
    ]
  ],
  "openalex": "W7206185291",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.08.28.26361349v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-08-28",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6n6rcmn6d5aj7.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:35Z",
      "native_id": "10.64898/2026.08.28.26361349",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.08.28.26361349v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2716|Hemoglobinopathies and Related Disorders",
      "subfield": "human-genetics"
    }
  ],
  "title": "Evaluating Mean Platelet Volume in relation to Disease Severity in Paediatric Sickle Cell Anaemia: A Cross-Sectional Study in Kwara State, North-Central Nigeria",
  "title_text": "Evaluating Mean Platelet Volume in relation to Disease Severity in Paediatric Sickle Cell Anaemia: A Cross-Sectional Study in Kwara State, North-Central Nigeria",
  "type": "preprint",
  "updated_at": "2026-10-30T12:17:35Z",
  "url": "https://research.draconitic.com/paper/6n6rcmn6d5aj7",
  "venue": "medRxiv",
  "versions": []
}