{
  "abstract": "Background: Serial interpretation of lung volumes requires assessing both reliability and agreement. We examined these properties in a historical clinical dataset. Methods: This retrospective secondary analysis included 72 participants, excluding seven same-session pre/post-bronchodilator pairs. The primary analysis used 19 separately dated pairs labelled pre-bronchodilator at both examinations; the expanded 65-pair analysis was exploratory. Documented intervals were two to three days; the investigator retrospectively confirmed separate-day examinations within six days for all 65 pairs. Total lung capacity (TLC) and residual volume (RV) were principal outcomes; functional residual capacity was secondary and available in the same 19 participants. Analyses included two-way mixed-effects, absolute-agreement, single-measure intraclass correlation coefficients (ICCs), Lin’s concordance correlation coefficient, Gaussian reference limits, empirical difference quantiles, and leave-one-out analyses. Results: Fourteen primary participants had recorded chronic obstructive pulmonary disease labels without independently verified diagnostic post-bronchodilator spirometry. Primary TLC and RV ICCs were 0.947 (95% bootstrap confidence interval 0.838–0.988) and 0.940 (0.818–0.974), respectively. Mean second-minus-first differences were −0.033 and −0.015 L, with Gaussian reference limits of −0.964 to 0.898 L and −0.934 to 0.904 L, respectively. Corresponding empirical 2.5th–97.5th percentiles were −1.122 to 0.641 L and −0.875 to 0.803 L. Removing one observation reduced the standard deviation of paired differences by up to 28.8% for TLC and 14.8% for RV. Conclusions: High reliability estimates coexisted with appreciable paired variation. Unverified technical quality and clinical stability preclude attributing this variation solely to measurement error or establishing clinical response thresholds.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Salerno, Italy",
    "Department of Respiratory Diseases, San Giuseppe Moscati Hospital, 83100 Avellino, Italy",
    "Department of Medicine and Health Sciences ‘Vincenzo Tiberio’, University of Molise, 86100 Campobasso, Italy",
    "Casa di Cura “Clinica Montevergine”, 83013 Mercogliano, Italy",
    "Department of Translational Medical Sciences, Federico II University of Naples, Via S. Pansini 5, 80131 Naples, Italy"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Carmine Izzo",
      "orcid": "0000-0001-8499-5428"
    },
    {
      "affs": [
        1
      ],
      "name": "Alessandro Izzo"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Pasquale Mone"
    },
    {
      "affs": [
        0
      ],
      "name": "Simona Musto",
      "orcid": "0009-0005-3680-5067"
    },
    {
      "affs": [
        0
      ],
      "name": "Michele Ciccarelli",
      "orcid": "0000-0003-2379-1960"
    },
    {
      "affs": [
        4
      ],
      "name": "Francesco Giallauria",
      "orcid": "0000-0003-4119-9397"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6nrb2gv0f4byt.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15197704",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666337/?tool=EBI",
  "id": "6nrb2gv0f4byt",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13666337",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2740|Chronic Obstructive Pulmonary Disease (COPD) Research"
    ]
  ],
  "openalex": "W7220464353",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13666337/pdf/?tool=EBI",
  "pmcid": "PMC13666337",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/6nrb2gv0f4byt.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "PMC:PMC13666337",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13666337"
    },
    {
      "first_seen": "2026-10-30T12:20:00Z",
      "native_id": "10.3390/jcm15197704",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/19/7704"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2740|Chronic Obstructive Pulmonary Disease (COPD) Research",
      "subfield": "general"
    }
  ],
  "title": "Between-Session Reliability and Agreement of Body-Plethysmographic Lung Volumes in a Legacy Pulmonary Function Cohort",
  "title_text": "Between-Session Reliability and Agreement of Body-Plethysmographic Lung Volumes in a Legacy Pulmonary Function Cohort",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:00Z",
  "url": "https://research.draconitic.com/paper/6nrb2gv0f4byt",
  "venue": "Journal of clinical medicine",
  "versions": []
}