{
  "abstract": "Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a rare autoinflammatory disorder, and adult-onset cases caused by somatic mosaic TNFRSF1A variants are exceptionally rare. A man in his 60s developed recurrent febrile episodes with rash and polyarthralgia and was initially misdiagnosed with a biliary infection and adult-onset Still's disease. Hybrid capture-based next-generation sequencing identified a somatic mosaic TNFRSF1A variant with a variant allele frequency of 19%, thus establishing the diagnosis of TRAPS. Treatment with canakinumab resulted in complete clinical remission and successful glucocorticoid tapering.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "name": "Aoi Warashina"
    },
    {
      "name": "Motoko Kanemoto"
    },
    {
      "name": "Yasuhiro Hakamata"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6pd006x9m8817.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.7226-26",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7226-26/_article",
  "id": "6pd006x9m8817",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7226-26/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "1312|Inflammasome and immune disorders"
    ]
  ],
  "openalex": "W7169575417",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7226-26/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-07-18",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/6pd006x9m8817.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.7226-26",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7226-26/_article"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Inflammasome and immune disorders",
      "subfield": "molecular-biology"
    }
  ],
  "title": "A Case of Adult-Onset TNF Receptor-Associated Periodic Syndrome (TRAPS) with Somatic Mosaicism Treated with an IL-1 Inhibitor",
  "title_text": "A Case of Adult-Onset TNF Receptor-Associated Periodic Syndrome (TRAPS) with Somatic Mosaicism Treated with an IL-1 Inhibitor",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/6pd006x9m8817",
  "venue": "Internal Medicine",
  "versions": []
}