{
  "abstract": "BACKGROUND AND PURPOSE: Advancements in neuroendovascular devices have enabled greater access to distal, tortuous vasculature. However, this expanded capability also increases the risk of serious hemorrhagic complications during device navigation. The aim of the study is to quantify how microcatheter position and microguidewire stiffness affect tip contact force at a distal MCA segment. MATERIALS AND METHODS: A moderate-tortuosity silicone model of the MCA was used to evaluate three 0.014-inch Synchro SELECT microguidewires (Soft, Standard, and Support) with a TrevoTrak microcatheter positioned proximally in the M1 or distally in the M2 segment. Tip contact forces at the distal end of the M2 segment were recorded with a digital force gauge serving as a standardized surrogate for the distal vessel wall during motorized controlled wire advancement. From the force-distance curves, tip contact force slopes (mN/mm) and maximum tip contact forces (mN) were calculated and statistically compared across wire types and catheter positions. RESULTS: < .01). Distal microcatheter positioning consistently produced approximately 3- to 6-fold higher tip contact force slopes and higher maximum tip contact forces than proximal positioning. CONCLUSIONS: Microcatheter tip position and microguidewire stiffness were the primary determinants of the tip contact force transmitted to distal vessel segments during neuroendovascular navigation in this model. Stiffer microguidewires exert significantly greater tip contact force, particularly when the microcatheter is positioned near the distal segment. Maintaining the microcatheter tip proximally attenuates these forces and offers a simple strategy to reduce mechanic loading of fragile distal branches during distal access procedures.",
  "abstract_shown": true,
  "affiliations": [
    "From the Department of Radiological Sciences (K.F., O.S., M.G., S.T., N.K.), David Geffen School of Medicine at UCLA, Los Angeles, California",
    "Department of Neurology (K. Sakuta), Jikei University School of Medicine, Tokyo, Japan",
    "Department of Neurosurgery (Y.H.), Shinshu University School of Medicine, Matsumoto, Japan",
    "Department of Neurology (A.M.), David Geffen School of Medicine at UCLA, Los Angeles, California",
    "Department of Neurosurgery (T.I.), Kitaharima Medical Center, Hyogo, Japan",
    "Center for Clinical Research and Innovation (T.I.), Kobe City Medical Center General Hospital, Kobe, Japan",
    "Department of Neurology (K. Suzuki), Nippon Medical School Hospital, Tokyo, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Keiko Fukuda",
      "orcid": "0000-0001-6057-2447"
    },
    {
      "affs": [
        1
      ],
      "name": "Kenichi Sakuta",
      "orcid": "0000-0002-7125-7482"
    },
    {
      "affs": [
        2
      ],
      "name": "Yoshiki Hanaoka"
    },
    {
      "affs": [
        3
      ],
      "name": "Amir Molaie"
    },
    {
      "affs": [
        0
      ],
      "name": "Omar Selim"
    },
    {
      "affs": [
        0
      ],
      "name": "Mahsa Ghovvati"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Taichiro Imahori"
    },
    {
      "affs": [
        6
      ],
      "name": "Kentaro Suzuki",
      "orcid": "0000-0001-7607-2607"
    },
    {
      "affs": [
        0
      ],
      "name": "Satoshi Tateshima",
      "orcid": "0000-0003-0060-0930"
    },
    {
      "affs": [
        0
      ],
      "name": "Naoki Kaneko",
      "orcid": "0000-0002-3579-7908"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/6ptc5ks8xn36t.bib",
  "cited_by": 0,
  "doi": "10.3174/ajnr.a9315",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13738272/",
  "id": "6ptc5ks8xn36t",
  "issns": [
    "0195-6108",
    "1936-959X"
  ],
  "landing_url": "https://doi.org/10.3174/ajnr.a9315",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Clinical"
    ],
    [
      "heading",
      "Neurointervention"
    ],
    [
      "openalex",
      "2728|Intracranial Aneurysms: Treatment and Complications"
    ]
  ],
  "openalex": "W7154245446",
  "pdf_url": null,
  "pmcid": "PMC13738272",
  "pmid": "41980821",
  "published": "2026-11-06",
  "publisher": "American Society of Neuroradiology",
  "ris": "https://research.draconitic.com/paper/6ptc5ks8xn36t.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:23:17Z",
      "native_id": "PMC13738272",
      "source": "pmc",
      "url": "https://doi.org/10.3174/ajnr.a9315"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Intracranial Aneurysms: Treatment and Complications",
      "subfield": "neurology"
    }
  ],
  "title": "Role of Microcatheter Tip Position and Microguidewire Stiffness in Safe Neuroendovascular Navigation of Distal Vessels",
  "title_text": "Role of Microcatheter Tip Position and Microguidewire Stiffness in Safe Neuroendovascular Navigation of Distal Vessels",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T12:23:17Z",
  "url": "https://research.draconitic.com/paper/6ptc5ks8xn36t",
  "venue": "AJNR: American Journal of Neuroradiology",
  "versions": []
}